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Estrogen Receptor alpha anticorps (AA 246-273)

ESR1 Reactivité: Humain, Souris WB, IF, IHC (p) Hôte: Lapin Polyclonal RB33807 unconjugated
N° du produit ABIN657470
  • Antigène Voir toutes Estrogen Receptor alpha (ESR1) Anticorps
    Estrogen Receptor alpha (ESR1) (Estrogen Receptor 1 (ESR1))
    Épitope
    • 30
    • 30
    • 28
    • 26
    • 24
    • 21
    • 17
    • 16
    • 16
    • 16
    • 16
    • 15
    • 14
    • 12
    • 11
    • 10
    • 9
    • 9
    • 9
    • 8
    • 7
    • 7
    • 7
    • 6
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    AA 246-273
    Reactivité
    • 464
    • 170
    • 162
    • 18
    • 18
    • 10
    • 7
    • 7
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    Humain, Souris
    Hôte
    • 375
    • 96
    • 2
    • 1
    Lapin
    Clonalité
    • 357
    • 119
    Polyclonal
    Conjugué
    • 214
    • 32
    • 21
    • 19
    • 15
    • 9
    • 9
    • 9
    • 9
    • 9
    • 9
    • 8
    • 8
    • 8
    • 8
    • 8
    • 8
    • 8
    • 8
    • 8
    • 8
    • 8
    • 7
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 1
    • 1
    Cet anticorp Estrogen Receptor alpha est non-conjugé
    Application
    • 341
    • 154
    • 140
    • 111
    • 94
    • 83
    • 80
    • 55
    • 33
    • 29
    • 23
    • 15
    • 9
    • 7
    • 7
    • 5
    • 5
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Homologie
    B, Hs, Pig, Rat
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogène
    This ESR1/ER antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 246-273 amino acids from the Central region of human ESR1/ER.
    Clone
    RB33807
    Isotype
    Ig Fraction
  • Indications d'application
    IF: 1:10~50. WB: 1:2000. WB: 1:2000. IHC-P: 1:100. IHC-P: 1:100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    ESR1/ER Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
    Date de péremption
    6 months
  • Zhu, Xu, Rashedi, Pavone, Kim, Woodruff, Burdette: "Human fallopian tube epithelium co-culture with murine ovarian follicles reveals crosstalk in the reproductive cycle." dans: Molecular human reproduction, Vol. 22, Issue 11, pp. 756-767, (2018) (PubMed).

    Wang, Zhou, Guan, Yu, Wang: "β-Estradiol antagonizes the inhibitory effects of caffeine in BMMSCs via the ERβ-mediated cAMP-dependent PKA pathway." dans: Toxicology, Vol. 394, pp. 1-10, (2018) (PubMed).

    Arslan, Yu, Burdette, Pavone, Hope, Woodruff, Kim: "Novel three dimensional human endocervix cultures respond to 28-day hormone treatment." dans: Endocrinology, Vol. 156, Issue 4, pp. 1602-9, (2015) (PubMed).

    Bi, Yang, Yu, Zhao, Zhao, He, Jing, Wang, Huang: "Pregnancy serum facilitates hepatitis E virus replication in vitro." dans: The Journal of general virology, Vol. 96, Issue Pt 5, pp. 1055-61, (2015) (PubMed).

  • Antigène
    Estrogen Receptor alpha (ESR1) (Estrogen Receptor 1 (ESR1))
    Autre désignation
    ESR1/ER (ESR1 Produits)
    Sujet
    This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in several transcript variants, which differ in their 5' UTRs and use different promoters.
    Poids moléculaire
    66216
    ID gène
    2099
    NCBI Accession
    NP_000116, NP_001116212, NP_001116213, NP_001116214
    UniProt
    P03372
    Pathways
    Nuclear Receptor Transcription Pathway, EGFR Signaling Pathway, Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Ribonucleoprotein Complex Subunit Organization, Ribosome Assembly
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