KIR2DS1 anticorps (AA 151-180)

N° du produit ABIN657823

Détail du produit anti-KIR2DS1 anticorps

Antigène: KIR2DS1 (Killer Cell Immunoglobulin Like Receptor 2DS1 (KIR2DS1))

Épitope: AA 151-180

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KIR2DS1 est non-conjugé

Application: ELISA, Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This KIR2DS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 151-180 amino acids from the Central region of human KIR2DS1.

Clone: RB34046

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: KIR2DS1 Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.

Date de péremption: 6 months

Détails sur KIR2DS1

Antigène: KIR2DS1 (Killer Cell Immunoglobulin Like Receptor 2DS1 (KIR2DS1))

Autre désignation: KIR2DS1 (KIR2DS1 Produits)

Synonymes: anticorps CD158H, anticorps CD158a, anticorps p50.1, anticorps killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 1, anticorps KIR2DS1

Sujet: Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules, thus, KIR proteins are thought to play an important role in regulation of the immune response.

Poids moléculaire: 33618

ID gène: 3806

NCBI Accession: NP_055327

UniProt: Q14954