This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogène
This CIDEA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 181-209 amino acids from the C-terminal region of human CIDEA.
anticorps CIDE-A, anticorps AW212747, anticorps CIDEA, anticorps cide-a, anticorps MGC89985, anticorps cell death-inducing DFFA-like effector a, anticorps cell death-inducing DNA fragmentation factor, alpha subunit-like effector A, anticorps cell death-inducing DFFA-like effector a L homeolog, anticorps CIDEA, anticorps Cidea, anticorps cidea, anticorps cidea.L
Sujet
This gene encodes the homolog of the mouse protein Cidea that has been shown to activate apoptosis. This activation of apoptosis is inhibited by the DNA fragmentation factor DFF45 but not by caspase inhibitors. Mice that lack functional Cidea have higher metabolic rates, higher lipolysis in brown adipose tissue and higher core body temperatures when subjected to cold. These mice are also resistant to diet-induced obesity and diabetes. This suggests that in mice this gene product plays a role in thermogenesis and lipolysis. Alternatively spliced transcripts have been identified.