ERCC1 anticorps (C-Term)

N° du produit ABIN658027

Cet anticorps Lapin Polyclonal détecte spécifiquement ERCC1 dans WB. Il présente une réactivité avec des échantillons de Humain et Souris.

Aperçu rapide pour ERCC1 anticorps (C-Term) (ABIN658027)

Antigène: ERCC1 (Excision Repair Cross Complementing Polypeptide-1 (ERCC1))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ERCC1 est non-conjugé

Application: Western Blotting (WB)

Clone: RB33896

Détail du produit anti-ERCC1 anticorps

Épitope: AA 268-297, C-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This ERCC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 268-297 amino acids from the C-terminal region of human ERCC1.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: ERCC1 Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.

Date de péremption: 6 months

Détails sur ERCC1

Antigène: ERCC1 (Excision Repair Cross Complementing Polypeptide-1 (ERCC1))

Autre désignation: ERCC1

Sujet: The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand.

Poids moléculaire: 32562

ID gène: 2067

NCBI Accession: NP_001159521, NP_001974, NP_973730

UniProt: P07992

Pathways: Réparation de l'ADN, Production of Molecular Mediator of Immune Response