Anthrax Protective Antigen anticorps (Internal Region)

N° du produit ABIN6655029

Détail du produit anti-Anthrax Protective Antigen anticorps

Antigène: Anthrax Protective Antigen (PA)

Épitope: Internal Region

Reactivité: Bacillus anthracis

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Anthrax Protective Antigen est non-conjugé

Application: Western Blotting (WB)

Purification: Anti-Anthrax Protective Antigen Antibody is sera. A BLAST analysis was used to suggest cross-reactivity with Anti-Anthrax PA from multiple species based on 100% homology with the immunizing sequence. Cross-reactivity with Anti-Anthrax PA from other sources has not been determined.

Immunogène:

Immunogen: Anthrax Protective Antigen Antibody was produced from whole rabbit serum prepared by repeated immunizations with a synthetic peptide corresponding to the internal region of the Anthrax PA protein.

Immunogen Type: Peptide

Information d'application

Indications d'application:

Application Note: Anti-Anthrax PA (Protective Antigen) Antibody is suitable for use in WB. Expect a band approximately 83 kDa on specific lysates. Specific conditions for reactivity should be optimized by the end user.

Western Blot Dilution: 1:100-1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer:

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Stabilizer: 0.05 % BSA

0.05 % (w/v) Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: RT,4 °C,-20 °C

Stockage commentaire: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Détails sur Anthrax Protective Antigen

Antigène: Anthrax Protective Antigen (PA)

Autre désignation: Anthrax Protective Antigen (PA Produits)

Sujet:

Synonyms: pag, Anthrax Protective Antigen, Anthrax toxins translocating protein, PA-83, Protective antigen PA-20, PA20, Protective antigen PA-63, PA63

Background: Anthrax PA (Protective Antigen) and Anthrax LF (Lethal Factor), along with Anthrax EF (Edema Factor), are toxins produced by Bacillus anthracis. All three of the proteins must be present for toxic entry into cells. Anthrax PA is secreted from Bacillus anthracis as an 83 kD (PA83) protein which is cleaved by furin protease, releasing a 20 kD fragment. The 63 kD portion (PA63) of the cleavage product forms a heptamer, which binds the toxins LF and EF. This complex enters via receptor-mediated endocytosis where LF and EF exert their toxic effects. Anthrax PA is ideal for researchers interested in Neurobiology research.

Gene Name: pagA

ID gène: 1158723

NCBI Accession: NP_052806

UniProt: P13423