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Cyclin L2 anticorps (AA 309-384)

Rockland 600-401-878 CCNL2 Reactivité: Humain WB, ELISA, IP Hôte: Lapin Polyclonal unconjugated
Rockland
N° du produit ABIN6655712
N° du produit (Fournisseur): 600-401-878
  • Antigène Voir toutes Cyclin L2 (CCNL2) Anticorps
    Cyclin L2 (CCNL2)
    Épitope
    • 10
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 309-384
    Reactivité
    • 21
    • 7
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 23
    Lapin
    Clonalité
    • 23
    Polyclonal
    Conjugué
    • 18
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp Cyclin L2 est non-conjugé
    Application
    • 21
    • 10
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunoprecipitation (IP)
    N° du produit (Fournisseur)
    600-401-878
    Fournisseur
    Rockland
    Fonction
    Cyclin L2 Antibody
    Réactivité croisée (Details)
    This antibody is specific for human Cyclin L2a and shows negligible reactivity to Cyclin L2b or Cyclin L1 isoforms.
    Purification
    This product is an affinity purified antibody produced by immunoaffinity chromatography using polypeptide coupled to agarose beads followed by solid phase adsorption(s) to remove any unwanted reactivities.
    Stérilité
    Sterile filtered
    Immunogène
    This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic polypeptide corresponding to amino acids 309-384 of Human Cyclin L2a protein.
    Isotype
    IgG
  • Indications d'application

    Immunoprecipitation_Dilution: 1:100

    ELISA_Dilution: 1:2,000 - 1:10,000

    Western_Blot_Dilution: 1:500 - 1:3,000

    Other: User Optimized

    Commentaires

    This affinity purified antibody has been tested for use in ELISA and western blot.   Specific conditions for reactivity should be optimized by the end user.  Expect a band ~ 58 kDa in size corresponding to Cyclin L2a by western blotting in the appropriate cell lysate or extract. Although not tested, this antibody is likely functional in immunohistochemistry, immunofluorescence, and immunoprecipitation.

    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer

    Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

    Stabilizer: None

    Preservative: 0.01 % (w/v) Sodium Azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Store vial at -20° C prior to opening.  Aliquot contents and freeze at -20° C or below for extended storage.  Avoid cycles of freezing and thawing.  Centrifuge product if not completely clear after standing at room temperature.  This product is stable for several weeks at 4° C as an undiluted liquid.  Dilute only prior to immediate use.
    Date de péremption
    12 months
  • Kren, Unger, Abedin, Vogel, Henzler, Ahmed, Trembley: "Preclinical evaluation of cyclin dependent kinase 11 and casein kinase 2 survival kinases as RNA interference targets for triple negative breast cancer therapy." dans: Breast cancer research : BCR, Vol. 17, pp. 19, (2015) (PubMed).

    Loyer, Trembley, Katona, Kidd, Lahti: "Role of CDK/cyclin complexes in transcription and RNA splicing." dans: Cellular signalling, Vol. 17, Issue 9, pp. 1033-51, (2005) (PubMed).

  • Antigène
    Cyclin L2 (CCNL2)
    Autre désignation
    Cyclin L2 (CCNL2 Produits)
    Sujet

    Synonyms: rabbit anti-Cyclin-L2 antibody, Cyclin L2, CCNL2, SB138, Paneth cell-enhanced expression protein, Cyclin Ania-6b, Paneth cell-enhanced expression protein, PCEE, Ania6b

    Background: Cyclin L (also referred to as CCNL) is encoded by two highly related genes Cyclin L1 and Cyclin L2 (CCNL1 and CCNL2, respectively).  Cyclin L2 can be alternatively spliced to produce two isoforms (known as 1 and 2 or alpha and beta). The Cyclin L2 gene is located approximately 100-200 kb from the PITSLRE/CDK11 protein kinase locus in human (1p36) and in a syngenetic location on mouse chromosome 4q.  Cyclin L2 is ubiquitous, expressed at much higher levels than Cyclin L1, and thus is likely the major partner for the CDK11p110 protein kinase.

    Gene Name: CCNL2, SB138

    ID gène
    81669, 14585859
    UniProt
    Q96S94
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