CASK anticorps

N° du produit ABIN6658140

Détail du produit anti-CASK anticorps

Antigène: CASK (Calcium/calmodulin-Dependent serine Protein Kinase (MAGUK Family) (CASK))

Reactivité: Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CASK est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

Réactivité croisée: Humain, Souris, Rat (Rattus), Xenopus laevis, Poisson zèbre (Danio rerio)

Purification: Anti-CASK Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with CASK from Mouse, Rat, Human, Zebrafish, and Xenopus based on 100% homology with the immunizing sequence. Cross-reactivity with CASK from other sources has not been determined. Scaffolds research.

Immunogène:

Immunogen: CASK Antibody was produced in mice by repeated immunizations with a fusion protein of rat CASK/Lin2.

Immunogen Type: Recombinant Protein

Clone: S56A-50

Isotype: IgG1

Information d'application

Indications d'application:

Immunohistochemistry Dilution: User Optimized

Application Note: Anti-CASK Antibody is suitable for use in WB, IP, and IHC. Expect a band approximately ~100 kDa on specific lysates. Specific conditions for reactivity should be optimized by the end user.

Immunoprecipitation Dilution: User Optimized

Western Blot Dilution: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer:

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Stabilizer: 50 % (v/v) Glycerol

Stock: RT,4 °C,-20 °C

Stockage commentaire: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Détails sur CASK

Antigène: CASK (Calcium/calmodulin-Dependent serine Protein Kinase (MAGUK Family) (CASK))

Autre désignation: CASK (CASK Produits)

Synonymes: anticorps CAKI, anticorps CAMGUK, anticorps CG13412, anticorps CG13413, anticorps CG6703, anticorps CMG, anticorps CMG/CASK, anticorps Caki, anticorps CamGUK, anticorps CamguK, anticorps Camguk, anticorps Cask, anticorps Cmg, anticorps DLin-2, anticorps Dmel\\CG6703, anticorps RE09582p, anticorps caki, anticorps camguk, anticorps cmg, anticorps dCASK, anticorps wu:fb70g06, anticorps CAGH39, anticorps FGS4, anticorps LIN2, anticorps MICPCH, anticorps MRXSNA, anticorps TNRC8, anticorps DXPri1, anticorps DXRib1, anticorps LIN-2, anticorps Pals3, anticorps mLin-2, anticorps CG6703 gene product from transcript CG6703-RF, anticorps Peripheral plasma membrane protein CASK, anticorps CAMK/CASK protein kinase, anticorps peripheral plasma membrane protein CASK, anticorps calcium/calmodulin-dependent serine protein kinase b, anticorps calcium/calmodulin-dependent serine protein kinase a, anticorps calcium/calmodulin dependent serine protein kinase, anticorps calcium/calmodulin-dependent serine protein kinase (MAGUK family), anticorps calcium/calmodulin-dependent serine protein kinase (MAGUK family) S homeolog, anticorps CASK, anticorps Bm1_33725, anticorps LOAG_17286, anticorps Tsp_03763, anticorps caskb, anticorps caska, anticorps Cask, anticorps cask.S

Sujet:

Synonyms: Peripheral plasma membrane protein CASK, Calcium/calmodulin-dependent serine protein kinase

Background: CASK (calmodulin sensitive kinase) is a ~112 kDa member of the membrane associated quanylate kinase (MAGUK) protein family. It is an adaptor protein with a calcium/calmodulin-dependent protein kinase domain, a SH3 domain, aguanylate kinase homology domain (GUK) and a PDZ domain. CASK links transmembrane proteins to the cytoskeleton and signaling molecules. In particular, CASK binds to Neurexin to stabilize pre- and post-synaptic structrures. While most of CASK proteins are cytoplasmic, a portion of the protein enters the nucleus, where it acts as a transcriptional co-activator. Manifesting the importance of CASK, transgenic mice with insertional mutations die within 24 hours of births. CASK is also localized in the nuclei of basal keratinocytes in newborn rodent skin and developing hair follicles. It may play a role in wound healing.

Gene Name: Cask

ID gène: 29647

NCBI Accession: NP_071520

UniProt: Q62915

Pathways: Synaptic Vesicle Exocytosis