WNK4 anticorps (AA 351-450) (Biotin)

N° du produit ABIN668528

Détail du produit anti-WNK4 anticorps (Biotin)

Antigène: WNK4 (WNK Lysine Deficient Protein Kinase 4 (WNK4))

Épitope: AA 351-450

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp WNK4 est conjugé à/à la Biotin

Application: ELISA, Western Blotting (WB)

Réactivité croisée: Souris

Homologie: Human,Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human WNK4

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur WNK4

Antigène: WNK4 (WNK Lysine Deficient Protein Kinase 4 (WNK4))

Autre désignation: WNK4 (WNK4 Produits)

Sujet:

Synonyms: PHA 2B, PHA2B, PRKWNK 4, PRKWNK4, Protein kinase lysine deficient 4, Protein kinase with no lysine 4, Serine/threonine protein kinase WNK4, WNK lysine deficient protein kinase 4, WNK4_HUMAN.

Background: Regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation which appears to prevent membrane trafficking of SLC12A3. Also inhibits the renal K(+)channel, KCNJ1, via a kinase-independent mechanism by which it induces clearance of the protein from the cell surface by clathrin-dependent endocytosis. WNK4 appears to act as a molecular switch that can vary the balance between NaCl reabsorption and K(+)secretion to maintain integrated homeostasis.

ID gène: 65266