MMP1 anticorps (AA 401-464)

N° du produit ABIN668931

Détail du produit anti-MMP1 anticorps

Antigène: MMP1 (Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1))

Épitope: AA 401-464

Reactivité: Humain, Souris, Rat, Porc

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MMP1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Réactivité croisée: Humain, Souris, Porc, Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from rat MMP1

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-MMP1 (ABIN668931)

Song, Luo, Wang, Li, Yang, Dai, Shen, Zhang, Zhang: "Effects of alendronate on lumbar intervertebral disc degeneration with bone loss in ovariectomized rats." dans: The spine journal : official journal of the North American Spine Society, (2017) (PubMed).

Ding, Wang, Zhu, Zhao, Wu, Chen: "Osteopontin stimulates matrix metalloproteinase expression through the nuclear factor-κB signaling pathway in rat temporomandibular joint and condylar chondrocytes." dans: American journal of translational research, Vol. 9, Issue 2, pp. 316-329, (2017) (PubMed).

Elkabir, El-Zehery, Mourad, Soliman, Helal, Refai, Grawish: "Efficacy of azithromycin and metronidazole combined therapy on rats' gingival overgrowth induced by cyclosporine-A: An experimental animal study." dans: Journal of oral biology and craniofacial research, Vol. 6, Issue 3, pp. 219-226, (2016) (PubMed).

Mohamed, El-Zehery, Mourad, Grawish: "Impact of three different mouthwashes on the incidence of gingival overgrowth induced by cyclosporine-A: a randomized controlled experimental animal study." dans: Oral surgery, oral medicine, oral pathology and oral radiology, Vol. 120, Issue 3, pp. 346-56, (2015) (PubMed).

Jiang, Tian, Wang, Yan, Liu, Liu, Song, Zhang, Shen, Zhang: "Effect of calcitonin pretreatment on naturally occurring intervertebral disc degeneration in guinea pig." dans: International journal of clinical and experimental medicine, Vol. 8, Issue 7, pp. 10367-79, (2015) (PubMed).

Luo, Zhang, Wang, Hu, Song, Zhang: "The inhibitory effect of salmon calcitonin on intervertebral disc degeneration in an ovariectomized rat model." dans: European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, (2014) (PubMed).

Détails sur MMP1

Antigène: MMP1 (Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1))

Autre désignation: MMP-1 (MMP1 Produits)

Synonymes: anticorps CLG, anticorps CLGN, anticorps Mmp1a, anticorps CG4859, anticorps Dm1-MMP, anticorps Dmel\\CG4859, anticorps MMP-1, anticorps MMP1, anticorps Mmp 1, anticorps dMMP1, anticorps dm1-MMP, anticorps dmmp1, anticorps l(2)k04809, anticorps mmp1, anticorps Mmp1, anticorps Mcol-A, anticorps Mcola, anticorps col4, anticorps mmp18, anticorps Clgn, anticorps matrix metallopeptidase 1, anticorps Matrix metalloproteinase 1, anticorps matrix metalloproteinase 1, anticorps matrix metallopeptidase 1 (interstitial collagenase), anticorps matrix metallopeptidase 1a (interstitial collagenase), anticorps matrix metallopeptidase 1 S homeolog, anticorps interstitial collagenase, anticorps matrix metallopeptidase 8 L homeolog, anticorps MMP1, anticorps Mmp1, anticorps RB11133, anticorps Mmp1a, anticorps mmp1.S, anticorps LOC100727966, anticorps mmp8.L

Sujet:

Synonyms: CLGN, CLG, 27 kDa interstitial collagenase, collagenase, fibroblast, Fibroblast collagenase, Interstitial collagenase, Matrix metallopeptidase 1 interstitial collagenase, Matrix metalloproteinase-1, Matrix metalloprotease 1, Matrix Metalloproteinase 1, MMP-1, MMP1, MMP1_HUMAN, OTTHUMP00000045866, MMP 1.

Background: The matrix metalloproteinases (MMPs) are a family of at least eighteen secreted and membrane bound zincendopeptidases. Collectively, these enzymes can degrade all the components of the extracellular matrix, including fibrillar and non fibrillar collagens, fibronectin, laminin and basement membrane glycoproteins. In general, a signal peptide, a propeptide, and a catalytic domain containing the highly conserved zinc binding site characterizes the structure of the MMPs. In addition, fibronectin like repeats, a hinge region, and a C terminal hemopexin like domain allow categorization of MMPs into the collagenase, gelatinase, stomelysin and membrane type MMP subfamilies. All MMPs are synthesized as proenzymes, and most of them are secreted from the cells as proenzymes. Thus, the activation of these proenzymes is a critical step that leads to extracellular matrix breakdown. MMPs are considered to play an important role in wound healing, apoptosis, bone elongation, embryo development, uterine involution, angiogenesis and tissue remodeling, and in diseases such as multiple sclerosis, Alzheimer's, malignant gliomas, lupus, arthritis, periodontis, glumerulonephritis, atherosclerosis, tissue ulceration, and in cancer cell invasion and metastasis.

ID gène: 300339

UniProt: B5DFD5