DNMT3A anticorps (AA 26-100)
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- Antigène Voir toutes DNMT3A Anticorps
- DNMT3A (DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A))
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Épitope
- AA 26-100
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp DNMT3A est non-conjugé
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Application
- Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Réactivité croisée
- Humain, Souris, Rat
- Homologie
- Cow
- Purification
- Purified by Protein A.
- Immunogène
- KLH conjugated synthetic peptide derived from human Dnmt3a
- Isotype
- IgG
- Top Product
- Discover our top product DNMT3A Anticorps primaire
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- Indications d'application
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WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Stock
- 4 °C,-20 °C
- Stockage commentaire
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- Date de péremption
- 12 months
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Methylation of Septin9 mediated by DNMT3a enhances hepatic stellate cells activation and liver fibrogenesis." dans: Toxicology and applied pharmacology, Vol. 315, pp. 35-49, (2016) (PubMed).
: "Prenatal cocaine exposure impairs cognitive function of progeny via insulin growth factor II epigenetic regulation." dans: Neurobiology of disease, Vol. 82, pp. 54-65, (2015) (PubMed).
: "
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Methylation of Septin9 mediated by DNMT3a enhances hepatic stellate cells activation and liver fibrogenesis." dans: Toxicology and applied pharmacology, Vol. 315, pp. 35-49, (2016) (PubMed).
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- Antigène
- DNMT3A (DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A))
- Autre désignation
- Dnmt3a (DNMT3A Produits)
- Synonymes
- anticorps DNMT3A, anticorps DNMT3A2, anticorps M.HsaIIIA, anticorps MmuIIIA, anticorps dnmt3a1, anticorps dnmt6, anticorps DNA methyltransferase 3 alpha, anticorps DNA methyltransferase 3A, anticorps DNA (cytosine-5-)-methyltransferase 3 alpha b, anticorps DNMT3A, anticorps Dnmt3a, anticorps dnmt3a, anticorps dnmt3ab
- Sujet
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Synonyms: TBRS, DNMT3A2, M.HsaIIIA, DNA (cytosine-5)-methyltransferase 3A, Dnmt3a, DNA methyltransferase HsaIIIA, DNA MTase HsaIIIA
Background: Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity.
- ID gène
- 1788
- UniProt
- Q9Y6K1
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