KIT Ligand anticorps (AA 151-250)

N° du produit ABIN669936

Détail du produit anti-KIT Ligand anticorps

Antigène: KIT Ligand (KITLG)

Épitope: AA 151-250

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KIT Ligand est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human SCF

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-KIT Ligand (ABIN669936)

Yin, Liang, Wang, Yan, Yin, Wu, Su: "Naringenin induces laxative effects by upregulating the expression levels of c-Kit and SCF, as well as those of aquaporin 3 in mice with loperamide-induced constipation." dans: International journal of molecular medicine, Vol. 41, Issue 2, pp. 649-658, (2018) (PubMed).

Lin, Tang, Cai, Wang, Li, Sui, Guo: "NPs/NPRs Signaling Pathways May Be Involved in Depression-Induced Loss of Gastric ICC by Decreasing the Production of mSCF." dans: PLoS ONE, Vol. 11, Issue 2, pp. e0149031, (2016) (PubMed).

Wang, Wang, Li, Liu, Jiang, Li, Cao, Zhao, Wang, Luo: "Silencing stem cell factor attenuates stemness and inhibits migration of cancer stem cells derived from Lewis lung carcinoma cells." dans: Tumour biology, Vol. 37, Issue 6, pp. 7213-27, (2016) (PubMed).

Goldstein, Goss, Hatzistergos, Rangel, Seidler, Saur, Hare: "Adult c-Kit(+) progenitor cells are necessary for maintenance and regeneration of olfactory neurons." dans: The Journal of comparative neurology, (2014) (PubMed).

Détails sur KIT Ligand

Antigène: KIT Ligand (KITLG)

Autre désignation: SCF (KITLG Produits)

Synonymes: anticorps Xkl-1, anticorps Xsl, anticorps Xsl-1, anticorps Xsl-2, anticorps steel, anticorps KITLG, anticorps SCF, anticorps kitl, anticorps kl-1, anticorps mgf, anticorps scf, anticorps FPH2, anticorps KL-1, anticorps Kitl, anticorps MGF, anticorps SF, anticorps SHEP7, anticorps Clo, anticorps Con, anticorps Gb, anticorps Kitlg, anticorps Mgf, anticorps SLF, anticorps Sl, anticorps blz, anticorps contrasted, anticorps 710-712, anticorps CSF, anticorps KITL, anticorps KIT ligand L homeolog, anticorps KIT ligand, anticorps kit ligand, anticorps kitlg.L, anticorps KITLG, anticorps kitlg, anticorps Kitl, anticorps Kitlg

Sujet:

Synonyms: SF, MGF, SCF, FPH2, KL-1, Kitl, SHEP7, Kit ligand, Mast cell growth factor, Stem cell factor, c-Kit ligand, KITLG

Background: Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins.

ID gène: 4254

UniProt: P21583

Pathways: Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway