Angiotensin II anticorps

N° du produit ABIN670521

Détail du produit anti-Angiotensin II anticorps

Antigène: Angiotensin II (Ang II)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Angiotensin II est non-conjugé

Application: Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité: The immunogen used generate this antibody is DRVYIHPF, corresponding to amino acids 34-41 of human Angiotensinogen.

Réactivité croisée: Humain

Purification: Purified by Protein A.

Immunogène: MAP conjugated synthetic peptide derived from human Angiotensin II

Isotype: IgG

Information d'application

Indications d'application: IHC-P 1:100-500
IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Références pour anticorps anti-Angiotensin II (ABIN670521)

Liu, Jiang, Zhang, Li, Li, Xie, Hu: "Pulmonary artery denervation improves pulmonary arterial hypertension induced right ventricular dysfunction by modulating the local renin-angiotensin-aldosterone system." dans: BMC cardiovascular disorders, Vol. 16, Issue 1, pp. 192, (2016) (PubMed).

Anand, Yiangou, Sinisi, Fox, MacQuillan, Quick, Korchev, Bountra, McCarthy, Anand: "Mechanisms underlying clinical efficacy of Angiotensin II type 2 receptor (AT2R) antagonist EMA401 in neuropathic pain: clinical tissue and in vitro studies." dans: Molecular pain, Vol. 11, pp. 38, (2015) (PubMed).

Détails sur Angiotensin II

Antigène: Angiotensin II (Ang II)

Autre désignation: Angiotensin II (Ang II Produits)

Synonymes: anticorps ANHU, anticorps SERPINA8, anticorps ANRT, anticorps Ang, anticorps AngII, anticorps PAT, anticorps AI265500, anticorps AngI, anticorps Aogen, anticorps Serpina8, anticorps angiotensinogen, anticorps angiotensinogen (serpin peptidase inhibitor, clade A, member 8), anticorps AGT, anticorps Agt

Sujet:

Synonyms: Alpha 1 antiproteinase, antitrypsin, Ang II, ANG III, Angiotensin I, Angiotensin II, Angiotensin III, Angiotensinogen, Angiotensinogen serpin peptidase inhibitor, clade A member 8, ANHU, Pre angiotensinogen, Serine or cysteine proteinase inhibitor, Serpin A8, SERPINA8, AT-2, AT-II, ANGT_HUMAN.

Background: Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. Angiotensin-2: acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone. Angiotensin-3: stimulates aldosterone release. Angiotensin 1-7: is a ligand for the G-protein coupled receptor MAS1. Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets.

ID gène: 183

Pathways: Signalistation JAK/STAT, ACE Inhibitor Pathway, EGFR Signaling Pathway, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Regulation of Lipid Metabolism by PPARalpha, Protein targeting to Nucleus, Feeding Behaviour, Regulation of long-term Neuronal Synaptic Plasticity