DMBT1 anticorps (AA 1701-1785)

N° du produit ABIN670626

Détail du produit anti-DMBT1 anticorps

Antigène: DMBT1 (Deleted in Malignant Brain Tumors 1 (DMBT1))

Épitope: AA 1701-1785

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DMBT1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Réactivité croisée: Souris

Homologie: Human,Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human GP340

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur DMBT1

Antigène: DMBT1 (Deleted in Malignant Brain Tumors 1 (DMBT1))

Autre désignation: GP340 (DMBT1 Produits)

Synonymes: anticorps GP340, anticorps muclin, anticorps CRP, anticorps CRP-[a], anticorps CRP-[b], anticorps Crpd, anticorps DBMT1, anticorps gp300, anticorps p80, anticorps DMBT1, anticorps gp340, anticorps deleted in malignant brain tumors 1, anticorps deleted in malignant brain tumors 1 protein, anticorps gp340, anticorps deleted in malignant brain tumors 1 S homeolog, anticorps DMBT1, anticorps Dmbt1, anticorps LOC100064515, anticorps dmbt1, anticorps ST201phi2-1p340, anticorps dmbt1.S

Sujet:

Synonyms: GP340, muclin, Deleted in malignant brain tumors 1 protein, Glycoprotein 340, Gp-340, Hensin, Salivary agglutinin, SAG, Surfactant pulmonary-associated D-binding protein, DMBT1, DMBT1/6kb.1

Background: May be considered as a candidate tumor suppressor gene for brain, lung, esophageal, gastric, and colorectal cancers. May play roles in mucosal defense system, cellular immune defense and epithelial differentiation. May play a role as an opsonin receptor for SFTPD and SPAR in macrophage tissues throughout the body, including epithelial cells lining the gastrointestinal tract. May play a role in liver regeneration. May be an important factor in fate decision and differentiation of transit-amplifying ductular (oval) cells within the hepatic lineage. Required for terminal differentiation of columnar epithelial cells during early embryogenesis. May function as a binding protein in saliva for the regulation of taste sensation. Binds to HIV-1 envelope protein and has been shown to both inhibit and facilitate viral transmission. Displays a broad calcium-dependent binding spectrum against both Gram-positive and Gram-negative bacteria, suggesting a role in defense against bacterial pathogens. Binds to a range of poly-sulfated and poly-phosphorylated ligands which may explain its broad bacterial-binding specificity. Inhibits cytoinvasion of S.enterica. Associates with the actin cytoskeleton and is involved in its remodeling during regulated exocytosis. Interacts with pancreatic zymogens in a pH -dependent manner and may act as a Golgi cargo receptor in the regulated secretory pathway of the pancreatic acinar cell.

ID gène: 1755

UniProt: Q9UGM3

Pathways: Activation of Innate immune Response