SYVN1 anticorps (AA 531-617)
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- Antigène Voir toutes SYVN1 Anticorps
- SYVN1 (Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1))
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Épitope
- AA 531-617
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Reactivité
- Humain, Souris
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp SYVN1 est non-conjugé
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Application
- Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Réactivité croisée
- Humain, Souris
- Homologie
- Rat,Dog,Cow
- Purification
- Purified by Protein A.
- Immunogène
- KLH conjugated synthetic peptide derived from human SYVN1
- Isotype
- IgG
- Top Product
- Discover our top product SYVN1 Anticorps primaire
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- Indications d'application
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WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Stock
- 4 °C,-20 °C
- Stockage commentaire
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- Date de péremption
- 12 months
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Experimental study of the protective effects of SYVN1 against diabetic retinopathy." dans: Scientific reports, Vol. 5, pp. 14036, (2016) (PubMed).
: "Endoplasmic reticulum-associated degradation controls cell surface expression of ?-aminobutyric acid, type B receptors." dans: The Journal of biological chemistry, Vol. 288, Issue 48, pp. 34897-905, (2013) (PubMed).
: "Expression of endoplasmic reticulum stress-related factors in the retinas of diabetic rats." dans: Experimental diabetes research, Vol. 2012, pp. 743780, (2011) (PubMed).
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Experimental study of the protective effects of SYVN1 against diabetic retinopathy." dans: Scientific reports, Vol. 5, pp. 14036, (2016) (PubMed).
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- Antigène
- SYVN1 (Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1))
- Autre désignation
- SYVN1 (SYVN1 Produits)
- Sujet
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Synonyms: DER3, HRD1, E3 ubiquitin-protein ligase synoviolin, Synovial apoptosis inhibitor 1, SYVN1, KIAA181
Background: Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins such as SGK. Protects cells from ER stress-induced apoptosis. Protects neurons from apoptosis induced by polyglutamine-expanded huntingtin (HTT) or unfolded GPR37 by promoting their degradation. Sequesters p53/TP53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis.
- ID gène
- 84447
- UniProt
- Q86TM6
- Pathways
- ER-Nucleus Signaling, Negative Regulation of intrinsic apoptotic Signaling
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