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RMI2 anticorps

RMI2 Reactivité: Humain, Souris, Rat WB, IHC (p) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6719656
  • Antigène Voir toutes RMI2 Anticorps
    RMI2 (RMI2, RecQ Mediated Genome Instability 2 (RMI2))
    Reactivité
    Humain, Souris, Rat
    Hôte
    • 1
    Lapin
    Clonalité
    • 1
    Polyclonal
    Conjugué
    • 1
    Cet anticorp RMI2 est non-conjugé
    Application
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Fonction
    Rabbit IgG polyclonal antibody for RMI2 detection. Tested with WB, IHC-P in Human,Mouse,Rat.
    Séquence
    KMTDLSDNPI HESMWELEVE DLHRNIP
    Réactivité croisée (Details)
    No cross reactivity with other proteins.
    Attributs du produit
    Rabbit IgG polyclonal antibody for RMI2 detection. Tested with WB, IHC-P in Human,Mouse,Rat.
    Purification
    Immunogen affinity purified.
    Immunogène
    A synthetic peptide corresponding to a sequence of human RMI2(KMTDLSDNPIHESMWELEVEDLHRNIP).
    Isotype
    IgG
    Top Product
    Discover our top product RMI2 Anticorps primaire
  • Indications d'application

    Application details: Western blot|0.1-0.5 μg/mL Immunohistochemistry(Paraffin-embedded Section)|0.5-1 μg/mL

    Commentaires

    Tested Species: In-house tested species with positive results. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Buffer
    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
  • Antigène
    RMI2 (RMI2, RecQ Mediated Genome Instability 2 (RMI2))
    Autre désignation
    RMI2 (RMI2 Produits)
    Synonymes
    anticorps BLAP18, anticorps C16orf75, anticorps C25H16orf75, anticorps C14H16orf75, anticorps A630055G03Rik, anticorps Gm537, anticorps Gm929, anticorps RecQ mediated genome instability 2, anticorps RMI2, anticorps Rmi2
    Sujet

    Synonyms: RecQ-mediated genome instability protein 2, hRMI2, BLM-associated protein of 18 kDa, BLAP18, RMI2, C16orf75

    Background: RMI2 is a component of the BLM (RECQL3) complex, which plays a role in homologous recombination-dependent DNA repair and is essential for genome stability. This gene is mapped to 16p13.13. RMI1 and RMI2 were present in approximately stoichiometric amounts with other BLM complex components, including topoisomerase-3-alpha (TOP3A), RPA (see RPA1), and BLAP250. RMI2 also associated with RMI1 and TOP3A in a second complex. RMI1 and RMI2 interacted directly, and both were essential for stability of the BLM complex. Depletion of either RMI1 or RMI2 depleted the other protein by 80 to 90 % . Chicken DT40 cells depleted of Rmi2 displayed elevated sister chromatid exchange, but other functions of the BLM complex appeared intact. Mutation analysis revealed that interaction between human RMI2 and BLM was essential for suppression of sister chromatid exchange.

    ID gène
    116028
    UniProt
    Q96E14
    Pathways
    Réparation de l'ADN
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