PPP1R13B anticorps (AA 901-1090)

N° du produit ABIN674379

Détail du produit anti-PPP1R13B anticorps

Antigène: PPP1R13B (Protein Phosphatase 1, Regulatory Subunit 13B (PPP1R13B))

Épitope: AA 901-1090

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PPP1R13B est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Réactivité croisée: Humain

Homologie: Mouse,Rat,Dog,Cow,Horse,Chicken

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human ASPP1

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-PPP1R13B (ABIN674379)

Xie, Yang, Chi, Yang, Wang, Xu: "Prognostic values of apoptosis-stimulating P53-binding protein 1 and 2 and their relationships with clinical characteristics of esophageal squamous cell carcinoma patients: a retrospective study." dans: Chinese journal of cancer, Vol. 36, Issue 1, pp. 15, (2017) (PubMed).

Détails sur PPP1R13B

Antigène: PPP1R13B (Protein Phosphatase 1, Regulatory Subunit 13B (PPP1R13B))

Autre désignation: ASPP1 (PPP1R13B Produits)

Synonymes: anticorps ASPP1, anticorps p53BP2-like, anticorps p85, anticorps AI449786, anticorps AW545810, anticorps Tp53bp2, anticorps Trp53bp2, anticorps protein phosphatase 1 regulatory subunit 13B, anticorps protein phosphatase 1, regulatory subunit 13B, anticorps protein phosphatase 1 regulatory subunit 13B L homeolog, anticorps protein phosphatase 1, regulatory subunit 13Bb, anticorps protein phosphatase 1, regulatory (inhibitor) subunit 13B, anticorps PPP1R13B, anticorps Ppp1r13b, anticorps ppp1r13b.L, anticorps ppp1r13bb, anticorps ppp1r13b

Sujet:

Synonyms: p53BP2 like, p85, PPP1R13B, apoptosis stimulating protein of P53 1, Apoptosis-stimulating of p53 protein 2, Tumor suppressor p53-binding protein 2, p53-binding protein 2, p53BP2, 53BP2, Bcl2-binding protein, Bbp, Renal carcinoma antigen NY-REN-51.

Background: iASPP (inhibitor of apoptosis stimulating protein of p53, RelA-associated inhibitor (RAI), NFKap B-interacting protein 1, protein phosphatase 1 regulatory subunit 13-like, PPP1R13L) is the third member of the ASPP family of proteins. Unlike ASPP1 and ASPP2, which interact with p53 and enhance its ability to induce apoptosis, iASPP inhibits apoptosis induced by p53 overexpression. iASPP has been identified in a yeast-two hybrid screen as an interacting protein of the p65 subunit of NFKap B (RelA),3 interacts with NFKap B in vivo, and acts as an efficient inhibitor of HIV-1 gene expression in which both NFKap b and Sp1 play major roles. iASPP expression is upregulated in human breast carcinomas expressing wild-type p53, and gene overexpression may play an important role in the leukemogenesis and/or progression of acute leukemia. Alternate Names: apoptosis stimulating protein of P53 1, Apoptosis-stimulating of p53 protein 2, Tumor suppressor p53-binding protein 2, p53-binding protein 2, p53BP2, 53BP2, Bcl2-binding protein, Bbp, Renal carcinoma antigen NY-REN-51.

ID gène: 23368

UniProt: Q96KQ4

Pathways: Signalisation p53