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CCL5 anticorps (AA 62-91)

CCL5 Reactivité: Humain, Souris, Cobaye, Porc ELISA, IHC (p), IF (p), IF (cc), IHC (fro) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN674949
  • Antigène Voir toutes CCL5 Anticorps
    CCL5 (Chemokine (C-C Motif) Ligand 5 (CCL5))
    Épitope
    • 38
    • 14
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 62-91
    Reactivité
    • 88
    • 47
    • 19
    • 19
    • 19
    • 16
    • 10
    • 5
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    Humain, Souris, Cobaye, Porc
    Hôte
    • 119
    • 30
    • 2
    • 1
    • 1
    Lapin
    Clonalité
    • 114
    • 38
    Polyclonal
    Conjugué
    • 71
    • 30
    • 15
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp CCL5 est non-conjugé
    Application
    • 105
    • 61
    • 53
    • 21
    • 16
    • 14
    • 14
    • 13
    • 13
    • 11
    • 9
    • 9
    • 8
    • 7
    • 4
    • 4
    • 4
    ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Frozen Sections) (IHC (fro))
     Réactivité croisée
    Cobaye, Humain, Souris, Porc
    Homologie
    Rat,Dog,Cow,Sheep,Rabbit
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human CCL5
    Isotype
    IgG
    Top Product
    Discover our top product CCL5 Anticorps primaire
  • Indications d'application
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Date de péremption
    12 months
  • Irie, Tomofuji, Ekuni, Fukuhara, Uchida, Kataoka, Kobayashi, Kikuchi, Mitani, Shimazaki, Morita: "Age-related changes of CD4+T cell migration and cytokine expression in germ-free and SPF mice periodontium." dans: Archives of oral biology, Vol. 87, pp. 72-78, (2018) (PubMed).

    Sun, Roberts, Mauerhan, Hanley: "Biological effects and osteoarthritic disease-modifying activity of small molecule CM-01." dans: Journal of orthopaedic research : official publication of the Orthopaedic Research Society, (2017) (PubMed).

    Sun, Haines, Roberts, Ruffolo, Mauerhan, Mihalko, Ingram, Cox, Hanley: "Disease-modifying effects of phosphocitrate and phosphocitrate-β-ethyl ester on partial meniscectomy-induced osteoarthritis." dans: BMC musculoskeletal disorders, Vol. 16, pp. 270, (2016) (PubMed).

    Hwaiz, Rahman, Syk, Zhang, Thorlacius: "Rac1-dependent secretion of platelet-derived CCL5 regulates neutrophil recruitment via activation of alveolar macrophages in septic lung injury." dans: Journal of leukocyte biology, (2015) (PubMed).

    Herder, Iskandar, Kegler, Hansmann, Elmarabet, Khan, Kalkuhl, Deschl, Baumgärtner, Ulrich, Beineke: "Dynamic Changes of Microglia/Macrophage M1 and M2 Polarization in Theiler's Murine Encephalomyelitis." dans: Brain pathology (Zurich, Switzerland), Vol. 25, Issue 6, pp. 712-23, (2015) (PubMed).

    Pattappa, Peroglio, Sakai, Mochida, Benneker, Alini, Grad: "CCL5/RANTES is a key chemoattractant released by degenerative intervertebral discs in organ culture." dans: European cells & materials, Vol. 27, pp. 124-36; discussion 136, (2014) (PubMed).

  • Antigène
    CCL5 (Chemokine (C-C Motif) Ligand 5 (CCL5))
    Autre désignation
    CCL5/RANTES (CCL5 Produits)
    Synonymes
    anticorps Rantes, anticorps Scya5, anticorps D17S136E, anticorps RANTES, anticorps SCYA5, anticorps SIS-delta, anticorps SISd, anticorps TCP228, anticorps eoCP, anticorps MuRantes, anticorps C-C motif chemokine 5-like, anticorps C-C motif chemokine ligand 5, anticorps chemokine (C-C motif) ligand 5, anticorps LOC100230935, anticorps CCL5, anticorps Ccl5
    Sujet

    Synonyms: SISd, eoCP, SCYA5, RANTES, TCP228, D17S136E, SIS-delta, C-C motif chemokine 5, Eosinophil chemotactic cytokine, Small-inducible cytokine A5, T cell-specific protein P228, T-cell-specific protein RANTES, CCL5

    Background: Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils (PubMed:1679162, PubMed:13864, PubMed:8525373, PubMed:9516414, PubMed:15923218). May also be an agonist of the G protein-coupled receptor GPR75, stimulating inositol trisphosphate production and calcium mobilization through its activation. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells (PubMed:23979485).

    ID gène
    6352
    UniProt
    P13501
    Pathways
    Cellular Response to Molecule of Bacterial Origin, Regulation of G-Protein Coupled Receptor Protein Signaling, Smooth Muscle Cell Migration
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