NRF2 anticorps (pSer40)
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- Antigène Voir toutes NRF2 (NFE2L2) Anticorps
- NRF2 (NFE2L2) (Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2))
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Épitope
- pSer40
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Reactivité
- Humain, Souris, Rat, Porc
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp NRF2 est non-conjugé
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Réactivité croisée
- Humain, Souris, Porc, Rat
- Homologie
- Dog,Cow,Chicken
- Purification
- Purified by Protein A.
- Immunogène
- KLH conjugated synthetic phosphopeptide derived from human Nrf2 around the phosphorylation site of Ser40 [DF(p-S)QR]
- Isotype
- IgG
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- Indications d'application
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WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Stock
- 4 °C,-20 °C
- Stockage commentaire
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- Date de péremption
- 12 months
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Insulin Inhibits Nrf2 Gene Expression via Heterogeneous Nuclear Ribonucleoprotein F/K in Diabetic Mice." dans: Endocrinology, Vol. 158, Issue 4, pp. 903-919, (2017) (PubMed).
: "Prolonged metformin treatment leads to reduced transcription of Nrf2 and neurotrophic factors without cognitive impairment in older C57BL/6J mice." dans: Behavioural brain research, Vol. 301, pp. 1-9, (2016) (PubMed).
: "Andrographolide stimulates p38 mitogen-activated protein kinase-nuclear factor erythroid-2-related factor 2-heme oxygenase 1 signaling in primary cerebral endothelial cells for definite protection ..." dans: Translational research : the journal of laboratory and clinical medicine, Vol. 170, pp. 57-72, (2016) (PubMed).
: "Crude Preparations of Helicobacter pylori Outer Membrane Vesicles Induce Upregulation of Heme Oxygenase-1 via Activating Akt-Nrf2 and mTOR-IκB Kinase-NF-κB Pathways in Dendritic Cells." dans: Infection and immunity, Vol. 84, Issue 8, pp. 2162-74, (2016) (PubMed).
: "Bacteroides fragilis Enterotoxin Upregulates Heme Oxygenase-1 in Intestinal Epithelial Cells via a Mitogen-Activated Protein Kinase- and NF-κB-Dependent Pathway, Leading to Modulation of Apoptosis." dans: Infection and immunity, Vol. 84, Issue 9, pp. 2541-54, (2016) (PubMed).
: "EX4 stabilizes and activates Nrf2 via PKCδ, contributing to the prevention of oxidative stress-induced pancreatic beta cell damage." dans: Toxicology and applied pharmacology, Vol. 315, pp. 60-69, (2016) (PubMed).
: "Resveratrol protects against methylglyoxal-induced hyperglycemia and pancreatic damage in vivo." dans: Nutrients, Vol. 7, Issue 4, pp. 2850-65, (2016) (PubMed).
: "Scopoletin Protects against Methylglyoxal-Induced Hyperglycemia and Insulin Resistance Mediated by Suppression of Advanced Glycation Endproducts (AGEs) Generation and Anti-Glycation." dans: Molecules (Basel, Switzerland), Vol. 20, Issue 2, pp. 2786-801, (2015) (PubMed).
: "Aripiprazole increases NAD(P)H-quinone oxidoreductase-1 and heme oxygenase-1 in PC12 cells." dans: Journal of neural transmission (Vienna, Austria : 1996), Vol. 122, Issue 6, pp. 757-72, (2015) (PubMed).
: "Melatonin induces the expression of Nrf2-regulated antioxidant enzymes via PKC and Ca(2+) influx activation in mouse pancreatic acinar cells." dans: Free radical biology & medicine, (2015) (PubMed).
: "The crosstalk between Nrf2 and AMPK signal pathways is important for the anti-inflammatory effect of berberine in LPS-stimulated macrophages and endotoxin-shocked mice." dans: Antioxidants & redox signaling, Vol. 20, Issue 4, pp. 574-88, (2014) (PubMed).
: "Valerian inhibits rat hepatocarcinogenesis by activating GABA(A) receptor-mediated signaling." dans: PLoS ONE, Vol. 9, Issue 11, pp. e113610, (2014) (PubMed).
: "Saponins from Aralia taibaiensis attenuate D-galactose-induced aging in rats by activating FOXO3a and Nrf2 pathways." dans: Oxidative medicine and cellular longevity, Vol. 2014, pp. 320513, (2014) (PubMed).
: "Mitigation of radiation-induced hematopoietic injury via regulation of cellular MAPK/phosphatase levels and increasing hematopoietic stem cells." dans: Free radical biology & medicine, Vol. 68, pp. 52-64, (2014) (PubMed).
: "Dimerumic acid attenuates receptor for advanced glycation endproducts signal to inhibit inflammation and diabetes mediated by Nrf2 activation and promotes methylglyoxal metabolism into d-lactic acid." dans: Free radical biology & medicine, Vol. 60, pp. 7-16, (2013) (PubMed).
: "Monascin and AITC attenuate methylglyoxal-induced PPAR? phosphorylation and degradation through inhibition of the oxidative stress/PKC pathway depending on Nrf2 activation." dans: Journal of agricultural and food chemistry, Vol. 61, Issue 25, pp. 5996-6006, (2013) (PubMed).
: "Graptopetalum paraguayense and resveratrol ameliorates carboxymethyllysine (CML)-induced pancreas dysfunction and hyperglycemia." dans: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, Vol. 62, pp. 492-8, (2013) (PubMed).
: "Ankaflavin: a natural novel PPAR? agonist upregulates Nrf2 to attenuate methylglyoxal-induced diabetes in vivo." dans: Free radical biology & medicine, Vol. 53, Issue 11, pp. 2008-16, (2012) (PubMed).
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Insulin Inhibits Nrf2 Gene Expression via Heterogeneous Nuclear Ribonucleoprotein F/K in Diabetic Mice." dans: Endocrinology, Vol. 158, Issue 4, pp. 903-919, (2017) (PubMed).
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- Antigène
- NRF2 (NFE2L2) (Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2))
- Autre désignation
- Nrf2 (NFE2L2 Produits)
- Sujet
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Synonyms: NRF2, Nuclear factor erythroid 2-related factor 2, NF-E2-related factor 2, NFE2-related factor 2, HEBP1, Nuclear factor, erythroid derived 2, like 2, NFE2L2
Background: Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.
- ID gène
- 4780
- UniProt
- Q16236
- Pathways
- ER-Nucleus Signaling, Negative Regulation of intrinsic apoptotic Signaling
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