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OLR1 anticorps (AA 201-273)

OLR1 Reactivité: Humain, Souris, Rat, Lapin WB, ELISA, ICC, FACS, IF (cc), IF (p), IHC (fro), IHC (p) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN676988
  • Antigène Voir toutes OLR1 Anticorps
    OLR1 (Oxidized Low Density Lipoprotein (Lectin-Like) Receptor 1 (OLR1))
    Épitope
    • 15
    • 6
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 201-273
    Reactivité
    • 62
    • 23
    • 20
    • 17
    • 2
    Humain, Souris, Rat, Lapin
    Hôte
    • 43
    • 23
    • 2
    • 1
    • 1
    • 1
    Lapin
    Clonalité
    • 47
    • 24
    Polyclonal
    Conjugué
    • 34
    • 5
    • 4
    • 4
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp OLR1 est non-conjugé
    Application
    • 43
    • 26
    • 19
    • 12
    • 12
    • 11
    • 10
    • 8
    • 7
    • 7
    • 5
    • 4
    • 3
    • 3
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
     Réactivité croisée
    Humain, Souris, Lapin, Rat
    Homologie
    Cow
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from Rabbit LOX-1
    Isotype
    IgG
  • Indications d'application
    WB 1:300-5000
    ELISA 1:500-1000
    FCM 1:20-100
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Date de péremption
    12 months
  • Shibata, Shibata, Maemura, Kondo, Harada-Shiba: "Pathological and molecular analyses of atherosclerotic lesions in ApoE-knockout mice." dans: Medical molecular morphology, (2017) (PubMed).

    Gao, Zhao, Li, Lin, Jiang, Wang, Hu, Xu, Peng, He, Zhu: "LOX-1 and TLR4 affect each other and regulate the generation of ROS in A. fumigatus keratitis." dans: International immunopharmacology, Vol. 40, pp. 392-399, (2016) (PubMed).

    Deng, Hu, Xin, Gang: "Resveratrol alleviates vascular inflammatory injury by inhibiting inflammasome activation in rats with hypercholesterolemia and vitamin D2 treatment." dans: Inflammation research : official journal of the European Histamine Research Society ... [et al.], Vol. 64, Issue 5, pp. 321-32, (2015) (PubMed).

    Li, Zhao, Che, Lin, Li, Hu, Jiang, Liu: "The Role of LOX-1 in Innate Immunity to Aspergillus fumigatus in Corneal Epithelial Cells." dans: Investigative ophthalmology & visual science, Vol. 56, Issue 6, pp. 3593-603, (2015) (PubMed).

    Wu, Tang, Jiang, Li, Jiang, Liu: "PCSK9 siRNA inhibits HUVEC apoptosis induced by ox-LDL via Bcl/Bax-caspase9-caspase3 pathway." dans: Molecular and cellular biochemistry, Vol. 359, Issue 1-2, pp. 347-58, (2011) (PubMed).

    Jeng, Dyson: "Direct measurement of the aspartic acid 26 pKa for reduced Escherichia coli thioredoxin by 13C NMR." dans: Biochemistry, Vol. 35, Issue 1, pp. 1-6, (1996) (PubMed).

  • Antigène
    OLR1 (Oxidized Low Density Lipoprotein (Lectin-Like) Receptor 1 (OLR1))
    Autre désignation
    LOX 1 (OLR1 Produits)
    Synonymes
    anticorps OLR1, anticorps LOX1, anticorps Olr1, anticorps CLEC8A, anticorps LOXIN, anticorps SCARE1, anticorps SLOX1, anticorps LOX-1, anticorps SR-EI, anticorps Scare1, anticorps Oldlr1, anticorps Oldr1, anticorps PLOX-1, anticorps oxidized low density lipoprotein receptor 1, anticorps oxidized low density lipoprotein (lectin-like) receptor 1, anticorps OLR1, anticorps Olr1
    Sujet

    Synonyms: LOX1, LOX-1, Oxidized low-density lipoprotein receptor 1, Ox-LDL receptor 1, Lectin-like oxidized LDL receptor 1, Lectin-like oxLDL receptor 1, Lectin-type oxidized LDL receptor 1, OLR1

    Background: Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria (By similarity).

    ID gène
    100009322
    UniProt
    Q9XTA8
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