Uromodulin anticorps (AA 351-450)

N° du produit ABIN678473

Détail du produit anti-Uromodulin anticorps

Antigène: Uromodulin (UMOD)

Épitope: AA 351-450

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Uromodulin est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Flow Cytometry (FACS), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Réactivité croisée: Humain, Souris, Rat

Homologie: Cow

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from Human Uromodulin

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-Uromodulin (ABIN678473)

Cho, Song, Oh, Kim, Ko, Lee, Jo: "Fate of Neutrophils during the Recovery Phase of Ischemia/Reperfusion Induced Acute Kidney Injury." dans: Journal of Korean medical science, Vol. 32, Issue 10, pp. 1616-1625, (2018) (PubMed).

Kim, Ko, Lee, Kim, Jo, Cho: "Blocking junctional adhesion molecule C promotes the recovery of cisplatin-induced acute kidney injury." dans: The Korean journal of internal medicine, Vol. 32, Issue 6, pp. 1053-1061, (2018) (PubMed).

Détails sur Uromodulin

Antigène: Uromodulin (UMOD)

Autre désignation: Uromodulin (UMOD Produits)

Synonymes: anticorps ADMCKD2, anticorps FJHN, anticorps HNFJ, anticorps HNFJ1, anticorps MCKD2, anticorps THGP, anticorps THP, anticorps urehr4, anticorps uromodulin, anticorps UMOD, anticorps Umod

Sujet:

Synonyms: ADMCKD2, FJHN, HNFJ, HNFJ1, MCKD2, medullary cystic kidney disease 2 autosomal dominant, Tamm Horsfall glycoprotein, Tamm Horsfall urinary glycoprotein, Tamm-Horsfall urinary glycoprotein, THGP, THP, Umod, UROM_HUMAN, Uromodulin.

Background: Uromodulin: Functions in biogenesis and organization of the apical membrane of epithelial cells of the thick ascending limb of Henle's loop (TALH), where it promotes formation of complex filamentous gel-like structure providing the water barrier permeability. May serve as a receptor for binding and endocytosis for cytokines (IL-1, IL-2) and TNF. Facilitates neutrophil migration across renal epithelia. Uromodulin, secreted form: Secreted into urine after proteolytical cleavage. Into the urine, may contribute to colloid osmotic pressure, retards passage of positively charged electrolytes, prevents urinary tract infection and modulates formation of supersaturated salts and their crystals.

ID gène: 7369

UniProt: P07911