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MTDH anticorps (AA 131-230)

MTDH Reactivité: Humain WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN678863
  • Antigène Voir toutes MTDH Anticorps
    MTDH (Metadherin (MTDH))
    Épitope
    • 15
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    AA 131-230
    Reactivité
    • 49
    • 18
    • 7
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 40
    • 7
    • 3
    Lapin
    Clonalité
    • 45
    • 5
    Polyclonal
    Conjugué
    • 28
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp MTDH est non-conjugé
    Application
    • 40
    • 14
    • 12
    • 12
    • 11
    • 9
    • 8
    • 8
    • 7
    • 3
    • 3
    • 2
    Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
     Réactivité croisée
    Humain
    Homologie
    Mouse,Rat,Dog,Cow,Pig
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human AEG-1
    Isotype
    IgG
    Top Product
    Discover our top product MTDH Anticorps primaire
  • Indications d'application
    WB 1:300-5000
    ELISA 1:500-1000
    FCM 1:20-100
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Date de péremption
    12 months
  • Zhang, Li, Qian, Liu, Guo, Lin: "MTDH/AEG-1-based DNA vaccine suppresses metastasis and enhances chemosensitivity to paclitaxel in pelvic lymph node metastasis." dans: Biomedicine & pharmacotherapy, Vol. 70, pp. 217-26, (2015) (PubMed).

    Guo, Zhang, Liu, Wang, Liu, Wang, Ma, Wu: "Astrocyte elevated gene-1 overexpression in histologically favorable Wilms tumor is related to poor prognosis." dans: Journal of pediatric urology, Vol. 10, Issue 2, pp. 317-23, (2014) (PubMed).

    Zheng, Li, Wu, Liu, Sun, Yang, Hao, Sheng, Sun, Zhang, Long, Liang, Hu et al.: "Astrocyte elevated gene-1 (AEG-1) shRNA sensitizes Huaier polysaccharide (HP)-induced anti-metastatic potency via inactivating downstream P13K/Akt pathway as well as augmenting cell-mediated immune ..." dans: Tumour biology, Vol. 35, Issue 5, pp. 4219-24, (2014) (PubMed).

    Guo, Chen, Xi, Chang, Zhang, Zhang: "AEG-1 expression correlates with CD133 and PPP6c levels in human glioma tissues." dans: Journal of biomedical research, Vol. 28, Issue 5, pp. 388-95, (2014) (PubMed).

  • Antigène
    MTDH (Metadherin (MTDH))
    Autre désignation
    LYRIC (MTDH Produits)
    Synonymes
    anticorps MGC75963, anticorps 2610103J23Rik, anticorps 3D3, anticorps 3D3/Lyric, anticorps AEG-1, anticorps AV353288, anticorps D8Bwg1112e, anticorps Lyric, anticorps AEG1, anticorps LYRIC, anticorps LYRIC/3D3, anticorps metadherin, anticorps mtdh, anticorps MTDH, anticorps Mtdh
    Sujet

    Synonyms: 3D3, AEG1, AEG-1, LYRIC, LYRIC/3D3, Protein LYRIC, 3D3/LYRIC, Astrocyte elevated gene-1 protein, Lysine-rich CEACAM1 co-isolated protein, Metadherin, Metastasis adhesion protein, MTDH

    Background: Downregulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance.

    ID gène
    92140
    UniProt
    Q86UE4
    Pathways
    Cellular Response to Molecule of Bacterial Origin, Cell-Cell Junction Organization
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