FZD5 anticorps (PE-Cy7)
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- Antigène Voir toutes FZD5 Anticorps
- FZD5 (Frizzled Family Receptor 5 (FZD5))
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Reactivité
- Humain, Souris, Rat, Boeuf (Vache), Chien, Porc
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp FZD5 est conjugé à/à la PE-Cy7
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Application
- Western Blotting (WB), Flow Cytometry (FACS)
- Réactivité croisée
- Humain, Souris, Rat
- Homologie
- Dog,Cow,Pig,Rabbit
- Purification
- Purified by Protein A.
- Immunogène
- KLH conjugated synthetic peptide derived from human Frizzled 5
- Isotype
- IgG
- Top Product
- Discover our top product FZD5 Anticorps primaire
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- Indications d'application
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IF (p) (1:100-500)
Not yet tested in other applications. Optimal working dilutions must be determined by the end user. - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Protect from light.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Date de péremption
- 12 months
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- Antigène
- FZD5 (Frizzled Family Receptor 5 (FZD5))
- Autre désignation
- Frizzled 5 (FZD5 Produits)
- Synonymes
- anticorps C2orf31, anticorps HFZ5, anticorps 5330434N09Rik, anticorps AI427138, anticorps Fz-5, anticorps Fz5, anticorps mFz5, anticorps Xfz5, anticorps frizzled5, anticorps frizzled5a, anticorps fz5, anticorps fzd5-A, anticorps fz2, anticorps fz8c, anticorps fzd8c, anticorps zg02, anticorps frizzled class receptor 5, anticorps frizzled class receptor 5 S homeolog, anticorps FZD5, anticorps Fzd5, anticorps fzd5.S, anticorps fzd5
- Sujet
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Synonyms: C2orf31, Frizzled homolog 5, Frizzled-5, Frizzled5, Fz 5, Fz-5, Fz5, FZD 5, hFz5, FZD5, FZD5_HUMAN, FzE 5, FzE5, HFZ 5, Seven transmembrane receptor frizzled 5, Wnt receptor, hFz8, Fz-8, Frizzled-8, FZD8.
Background: Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The Frizzled 5 protein is believed to be the receptor for the Wnt5A ligand. Frizzled 5 has been reported to be expressed in fetal kidney, fetal and adult liver, fetal lung, and adult pancreas. ESTs have been isolated from bone, liver/spleen, placenta, and prostate libraries. Frizzled 5 was cloned from a retina cDNA library. Receptor for Wnt proteins. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1.
- Poids moléculaire
- 62 kDa
- ID gène
- 7855, 8325
- Pathways
- Signalisation WNT
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