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Sorting Nexin 1 anticorps (AA 401-522) (Biotin)

SNX1 Reactivité: Rat ELISA, IHC (p), IHC (fro) Hôte: Lapin Polyclonal Biotin
N° du produit ABIN682080
  • Antigène Voir toutes Sorting Nexin 1 (SNX1) Anticorps
    Sorting Nexin 1 (SNX1)
    Épitope
    • 14
    • 12
    • 8
    • 6
    • 4
    • 4
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 401-522
    Reactivité
    • 59
    • 39
    • 22
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Rat
    Hôte
    • 67
    • 5
    • 3
    • 1
    Lapin
    Clonalité
    • 65
    • 11
    Polyclonal
    Conjugué
    • 32
    • 6
    • 6
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp Sorting Nexin 1 est conjugé à/à la Biotin
    Application
    • 39
    • 30
    • 14
    • 14
    • 12
    • 7
    • 6
    • 5
    • 2
    • 2
    • 1
    • 1
    ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
     Réactivité croisée
    Rat
    Homologie
    Human,Mouse,Dog,Pig,Horse,Chicken,Rabbit
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human SNX1/Sorting nexin1.
    Isotype
    IgG
    Top Product
    Discover our top product SNX1 Anticorps primaire
  • Indications d'application
    IHC-P 1:200-400
    IHC-F 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C for 12 months.
    Date de péremption
    12 months
  • Antigène
    Sorting Nexin 1 (SNX1)
    Autre désignation
    SNX1 (SNX1 Produits)
    Synonymes
    anticorps d254, anticorps sb:cb923, anticorps snx1, anticorps wu:fb40c08, anticorps wu:fj65g09, anticorps MGC82200, anticorps SNX1, anticorps HsT17379, anticorps VPS5, anticorps ARABIDOPSIS THALIANA SORTING NEXIN 1, anticorps ATSNX1, anticorps K16F4.11, anticorps K16F4_11, anticorps sorting nexin 1, anticorps sorting nexin 1a, anticorps sorting nexin 1 L homeolog, anticorps sorting nexin 1, anticorps sorting nexin-1, anticorps snx1a, anticorps snx1.L, anticorps SNX1, anticorps snx1, anticorps LOC100380673, anticorps Snx1
    Sujet

    Synonyms: VPS5, HsT17379, Sorting nexin-1, SNX1

    Background: Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:12198132). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity (PubMed:19816406, PubMed:23085988). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptors (IGF2R, M6PR and SORT1) and Shiginella dysenteria toxin stxB. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi (PubMed:12198132, PubMed:15498486, PubMed:17550970, PubMed:17101778, PubMed:18088323, PubMed:21040701). Involvement in retromer-independent endocytic trafficking of P2RY1 and lysosomal degradation of protease-activated receptor-1/F2R (PubMed:16407403, PubMed:20070609). Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation, the function is dependent on GEF activity of KALRN (PubMed:20604901). Required for endocytosis of DRD5 upon agonist stimulation but not for basal receptor trafficking (PubMed:23152498).

    ID gène
    6642
    UniProt
    Q13596
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