Sorting Nexin 1 anticorps (AA 401-522) (Biotin)

N° du produit ABIN682080

Détail du produit anti-Sorting Nexin 1 anticorps (Biotin)

Antigène: Sorting Nexin 1 (SNX1)

Épitope: AA 401-522

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Sorting Nexin 1 est conjugé à/à la Biotin

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Réactivité croisée: Rat

Homologie: Human,Mouse,Dog,Pig,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human SNX1/Sorting nexin1.

Isotype: IgG

Information d'application

Indications d'application: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur Sorting Nexin 1

Antigène: Sorting Nexin 1 (SNX1)

Autre désignation: SNX1 (SNX1 Produits)

Synonymes: anticorps d254, anticorps sb:cb923, anticorps snx1, anticorps wu:fb40c08, anticorps wu:fj65g09, anticorps MGC82200, anticorps SNX1, anticorps HsT17379, anticorps VPS5, anticorps ARABIDOPSIS THALIANA SORTING NEXIN 1, anticorps ATSNX1, anticorps K16F4.11, anticorps K16F4_11, anticorps sorting nexin 1, anticorps sorting nexin 1a, anticorps sorting nexin 1 L homeolog, anticorps sorting nexin 1, anticorps sorting nexin-1, anticorps snx1a, anticorps snx1.L, anticorps SNX1, anticorps snx1, anticorps LOC100380673, anticorps Snx1

Sujet:

Synonyms: VPS5, HsT17379, Sorting nexin-1, SNX1

Background: Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:12198132). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity (PubMed:19816406, PubMed:23085988). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptors (IGF2R, M6PR and SORT1) and Shiginella dysenteria toxin stxB. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi (PubMed:12198132, PubMed:15498486, PubMed:17550970, PubMed:17101778, PubMed:18088323, PubMed:21040701). Involvement in retromer-independent endocytic trafficking of P2RY1 and lysosomal degradation of protease-activated receptor-1/F2R (PubMed:16407403, PubMed:20070609). Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation, the function is dependent on GEF activity of KALRN (PubMed:20604901). Required for endocytosis of DRD5 upon agonist stimulation but not for basal receptor trafficking (PubMed:23152498).

ID gène: 6642

UniProt: Q13596