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EPH Receptor A2 anticorps (pTyr594)

EPHA2 Reactivité: Humain WB, ELISA, IF (p), IHC (p), IF (cc), IHC (fro) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN684508
  • Antigène Voir toutes EPH Receptor A2 (EPHA2) Anticorps
    EPH Receptor A2 (EPHA2)
    Épitope
    • 18
    • 15
    • 15
    • 15
    • 8
    • 8
    • 8
    • 8
    • 8
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 6
    • 6
    • 6
    • 6
    • 5
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pTyr594
    Reactivité
    • 168
    • 127
    • 69
    • 14
    • 6
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 176
    • 20
    • 4
    • 1
    Lapin
    Clonalité
    • 174
    • 26
    • 1
    Polyclonal
    Conjugué
    • 69
    • 18
    • 10
    • 10
    • 10
    • 10
    • 10
    • 10
    • 9
    • 8
    • 8
    • 7
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp EPH Receptor A2 est non-conjugé
    Application
    • 117
    • 68
    • 26
    • 23
    • 16
    • 13
    • 12
    • 7
    • 7
    • 7
    • 6
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Specificité
    This phosphorylation site is homologous to Tyr595 in Mouse and Rat. Due to the highly conserved nature of this protein to EphA4 and EphA5, this antibody may react with these EphA4 when phosphorylated at Tyr602 (hu, mu, rt) and EphA5 when phosphorylated at Tyr656 in Human, Tyr495 in Mouse, and Tyr658 in Rat.
     Réactivité croisée
    Humain
    Homologie
    Mouse,Rat,Dog,Cow,Pig,Horse,Chicken,Rabbit
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic phosphopeptide derived from human EphA2 around the phosphorylation site of Tyr594
    Isotype
    IgG
    Top Product
    Discover our top product EPHA2 Anticorps primaire
  • Indications d'application
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Date de péremption
    12 months
  • Antigène
    EPH Receptor A2 (EPHA2)
    Autre désignation
    EphA2 (EPHA2 Produits)
    Synonymes
    anticorps ARCC2, anticorps CTPA, anticorps CTPP1, anticorps CTRCT6, anticorps ECK, anticorps epha2, anticorps MGC89505, anticorps AW545284, anticorps Eck, anticorps Myk2, anticorps Sek-2, anticorps Sek2, anticorps id:ibd5152, anticorps rtk6, anticorps G42, anticorps XE10, anticorps epha2-A, anticorps EPH receptor A2, anticorps Eph receptor A2, anticorps epoxide hydrolase, anticorps eph receptor A2 a, anticorps EPH receptor A2 L homeolog, anticorps EPHA2, anticorps Epha2, anticorps epha2, anticorps ephA2, anticorps epha2a, anticorps epha2.L
    Sujet

    Synonyms: ECK, CTPA, ARCC2, CTPP1, CTRCT6, Ephrin type-A receptor 2, Epithelial cell kinase, Tyrosine-protein kinase receptor ECK, EPHA2

    Background: Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development and epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis.

    ID gène
    1969
    UniProt
    P29317
    Pathways
    Signalisation RTK
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