Lipocalin 2 anticorps (AA 101-198)

N° du produit ABIN685627

Détail du produit anti-Lipocalin 2 anticorps

Antigène: Lipocalin 2 (LCN2)

Épitope: AA 101-198

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Lipocalin 2 est non-conjugé

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Réactivité croisée: Humain

Homologie: Mouse,Rat,Dog,Cow,Pig,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human Lipocalin 2

Isotype: IgG

Information d'application

Indications d'application: ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-Lipocalin 2 (ABIN685627)

Xu, Zhang, Cheng, Liu, Zou, Zhan, Xiao, Xia: "Transcription factor 7-like 1 dysregulates keratinocyte differentiation through upregulating lipocalin 2." dans: Cell death discovery, Vol. 2, pp. 16028, (2016) (PubMed).

Xing, Wang, Cheng, Montaner, Mandeville, Leung, van Leyen, Lok, Wang, Lo: "Neuronal production of lipocalin-2 as a help-me signal for glial activation." dans: Stroke; a journal of cerebral circulation, Vol. 45, Issue 7, pp. 2085-92, (2014) (PubMed).

Détails sur Lipocalin 2

Antigène: Lipocalin 2 (LCN2)

Autre désignation: Lipocalin 2 (LCN2 Produits)

Synonymes: anticorps LCN2, anticorps 24p3, anticorps MSFI, anticorps NGAL, anticorps AW212229, anticorps Sip24, anticorps lipocalin 2, anticorps LCN2, anticorps Lcn2

Sujet:

Synonyms: 24p3, MSFI, NGAL, Neutrophil gelatinase-associated lipocalin, 25 kDa alpha-2-microglobulin-related subunit of MMP-9, Lipocalin-2, Oncogene 24p3, Siderocalin LCN2, p25, LCN2, HNL

Background: Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth.

ID gène: 3934

UniProt: P80188

Pathways: Cellular Response to Molecule of Bacterial Origin, Transition Metal Ion Homeostasis