ERBB3 anticorps (AA 661-760)

N° du produit ABIN686767

Détail du produit anti-ERBB3 anticorps

Antigène: ERBB3 (Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3))

Épitope: AA 661-760

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ERBB3 est non-conjugé

Application: ELISA, Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Réactivité croisée: Humain, Souris, Rat

Homologie: Dog,Cow,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human ErbB-3

Isotype: IgG

Information d'application

Indications d'application: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-ERBB3 (ABIN686767)

Cao, Chen, Chen, Xiong: "Positive prognostic value of HER2-HER3 co-expression and p-mTOR in gastric cancer patients." dans: BMC cancer, Vol. 17, Issue 1, pp. 841, (2018) (PubMed).

Xiao, Pepe, Wang, Luo, Zhang, Zeng, Zhang, Hu, Ye, Xu: "Nrf3-Pla2g7 interaction plays an essential role in smooth muscle differentiation from stem cells." dans: Arteriosclerosis, thrombosis, and vascular biology, Vol. 32, Issue 3, pp. 730-44, (2012) (PubMed).

Détails sur ERBB3

Antigène: ERBB3 (Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3))

Autre désignation: ErbB-3/HER3 (ERBB3 Produits)

Synonymes: anticorps ErbB-3, anticorps HER3, anticorps LCCS2, anticorps MDA-BF-1, anticorps c-erbB-3, anticorps c-erbB3, anticorps erbB3-S, anticorps p180-ErbB3, anticorps p45-sErbB3, anticorps p85-sErbB3, anticorps ERBB3, anticorps C76256, anticorps Erbb-3, anticorps Erbb3r, anticorps Her3, anticorps nuc-ErbB3, anticorps erb-b2 receptor tyrosine kinase 3, anticorps v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian), anticorps ERBB3, anticorps Erbb3

Sujet:

Synonyms: HER3, LCCS2, ErbB-3, c-erbB3, erbB3-S, MDA-BF-1, c-erbB-3, p180-ErbB3, p45-sErbB3, p85-sErbB3, Receptor tyrosine-protein kinase erbB-3, Proto-oncogene-like protein c-ErbB-3, Tyrosine kinase-type cell surface receptor HER3, ERBB3

Background: The ErbB3 gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. ErbB3 is a membrane-bound protein which has a neuregulin binding domain but not an active kinase domain. It can therefore bind this ligand but cannot convey a signal into the cell via protein phosphorylation. However it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers including prostate, bladder and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported but they have not been thoroughly characterized.

ID gène: 2065

UniProt: P21860

Pathways: Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway