SNCA anticorps (pSer129)

N° du produit ABIN6932860

Détail du produit anti-SNCA anticorps

Antigène: SNCA (Synuclein, alpha (SNCA))

Épitope: AA 124-134, pSer129

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp SNCA est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Specificité: Expressed principally in brain but is also expressed in low concentrations in all tissues examined except in liver. Concentrated in presynaptic nerve terminals.,Binds to phosphorylated serine 129 on alpha synuclein. Does not detect unphosphorylated serine 129 alpha synuclein

Réactivité croisée: Humain, Souris

Purification: Affinity Purified

Immunogène: Human alpha synuclein AA 124-134: AYEMP-pS-EEGYQ-Cys

Clone: J18

Isotype: IgG

Information d'application

Indications d'application:

• WB (1:500)
• optimal dilutions for assays should be determined by the user.

Commentaires:

A 1:500 dilution of ABIN6932860 was sufficient for detection of Alpha Synuclein pSer129 in 10 μg of Mouse Brain by ECL immunoblot analysis using Goat Anti-Rabbit IgG:HRP as the secondary antibody.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS pH 7.4, 50 % glycerol, 0.09 % Sodium azide, Storage buffer may change when conjugated

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: -20°C

Détails sur SNCA

Antigène: SNCA (Synuclein, alpha (SNCA))

Autre désignation: Alpha Synuclein (SNCA Produits)

Synonymes: anticorps snca, anticorps MGC64356, anticorps LOC619283, anticorps NACP, anticorps alphaSYN, anticorps PARK1, anticorps PARK4, anticorps PD1, anticorps synuclein alpha L homeolog, anticorps alpha-synuclein, anticorps synuclein alpha, anticorps synuclein, alpha, anticorps snca.L, anticorps LOC619283, anticorps SNCA, anticorps Snca

Sujet: Alpha-Synuclein (SNCA) is expressed predominantly in the brain, where it is concentrated in presynaptic nerve terminals (1). Alpha-synuclein is highly expressed in the mitochondria of the olfactory bulb, hippocampus, striatum and thalamus (2). Functionally, it has been shown to significantly interact with tubulin (3), and may serve as a potential microtubule-associated protein. It has also been found to be essential for normal development of the cognitive functions, inactivation may lead to impaired spatial learning and working memory (4). SNCA fibrillar aggregates represent the major non A-beta component of Alzheimers disease amyloid plaque, and a major component of Lewy body inclusions, and Parkinson's disease. Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the progressive accumulation in selected neurons of protein inclusions containing alpha-synuclein and ubiquitin (5, 6). Alpha synuclein phosphorylated at serine 129 constitutes 90 % of the alpha synuclein found in Lewy bodies (7, 8).

ID gène: 6622

NCBI Accession: NP_000336

UniProt: P37840

Pathways: Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Platelet-derived growth Factor Receptor Signaling, Negative Regulation of Transporter Activity, Regulation of long-term Neuronal Synaptic Plasticity