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SNCA anticorps (pSer129) (FITC)

SNCA Reactivité: Humain WB, ELISA, IHC, ICC Hôte: Lapin Monoclonal J18 FITC
N° du produit ABIN6932878
  • Antigène Voir toutes SNCA Anticorps
    SNCA (Synuclein, alpha (SNCA))
    Épitope
    • 68
    • 29
    • 28
    • 17
    • 16
    • 15
    • 14
    • 11
    • 9
    • 5
    • 4
    • 4
    • 4
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    • 3
    • 3
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    • 2
    • 2
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    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 124-134, pSer129
    Reactivité
    • 294
    • 190
    • 189
    • 14
    • 10
    • 10
    • 9
    • 7
    • 7
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 227
    • 105
    • 5
    • 3
    • 1
    • 1
    Lapin
    Clonalité
    • 217
    • 126
    Monoclonal
    Conjugué
    • 147
    • 24
    • 21
    • 16
    • 11
    • 8
    • 8
    • 7
    • 7
    • 7
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 2
    Cet anticorp SNCA est conjugé à/à la FITC
    Application
    • 226
    • 164
    • 110
    • 73
    • 68
    • 65
    • 56
    • 52
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    • 41
    • 23
    • 18
    • 10
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    • 7
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC)
    Specificité
    Expressed principally in brain but is also expressed in low concentrations in all tissues examined except in liver. Concentrated in presynaptic nerve terminals.,Binds to phosphorylated serine 129 on alpha synuclein. Does not detect unphosphorylated serine 129 alpha synuclein
     Réactivité croisée
    Humain, Souris
    Purification
    Affinity Purified
    Immunogène
    Human alpha synuclein AA 124-134: AYEMP-pS-EEGYQ-Cys
    Clone
    J18
    Isotype
    IgG
    Top Product
    Discover our top product SNCA Anticorps primaire
  • Indications d'application
    • WB (1:500)
    • optimal dilutions for assays should be determined by the user.
    Commentaires

    A 1:500 dilution of ABIN6932878 was sufficient for detection of Alpha Synuclein pSer129 in 10 μg of Mouse Brain by ECL immunoblot analysis using Goat Anti-Rabbit IgG:HRP as the secondary antibody.

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS pH 7.4, 50 % glycerol, 0.09 % Sodium azide, Storage buffer may change when conjugated
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C
    Stockage commentaire
    Conjugated antibodies should be stored at 4°C
  • Antigène
    SNCA (Synuclein, alpha (SNCA))
    Autre désignation
    Alpha Synuclein (SNCA Produits)
    Synonymes
    anticorps snca, anticorps MGC64356, anticorps LOC619283, anticorps NACP, anticorps alphaSYN, anticorps PARK1, anticorps PARK4, anticorps PD1, anticorps synuclein alpha L homeolog, anticorps alpha-synuclein, anticorps synuclein alpha, anticorps synuclein, alpha, anticorps snca.L, anticorps LOC619283, anticorps SNCA, anticorps Snca
    Sujet
    Alpha-Synuclein (SNCA) is expressed predominantly in the brain, where it is concentrated in presynaptic nerve terminals (1). Alpha-synuclein is highly expressed in the mitochondria of the olfactory bulb, hippocampus, striatum and thalamus (2). Functionally, it has been shown to significantly interact with tubulin (3), and may serve as a potential microtubule-associated protein. It has also been found to be essential for normal development of the cognitive functions, inactivation may lead to impaired spatial learning and working memory (4). SNCA fibrillar aggregates represent the major non A-beta component of Alzheimers disease amyloid plaque, and a major component of Lewy body inclusions, and Parkinson's disease. Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the progressive accumulation in selected neurons of protein inclusions containing alpha-synuclein and ubiquitin (5, 6). Alpha synuclein phosphorylated at serine 129 constitutes 90 % of the alpha synuclein found in Lewy bodies (7, 8).
    ID gène
    6622
    NCBI Accession
    NP_000336
    UniProt
    P37840
    Pathways
    Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Platelet-derived growth Factor Receptor Signaling, Negative Regulation of Transporter Activity, Regulation of long-term Neuronal Synaptic Plasticity
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