Recombinant Desmocollin 2 anticorps

N° du produit ABIN6937105

Détail du produit anti-Desmocollin 2 anticorps

Antigène: Desmocollin 2 (DSC2)

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Desmocollin 2 est non-conjugé

Application: ELISA, Coating (Coat)

Specificité: Desmosomes are intercellular adhering junctions that represent cell surface attachment sites for intermediate filament. The desmosome is subdivided into two regions. The plaque region lies adjacent to the plasma, and is believed to contain molecules that attach the intermediate filament cytoskeleton to the desmosome. The core region is composed of transmembrane glycoproteins that are thought to mediate cell-cell adhesion. Desmogleins and desmocollins are the main desmosomal transmembrane proteins. These desmosomal glycoproteins belong to the members of the cadherin family of adhesion molecules. Three different isoforms of both desmogleins and desmocollins have been identified, named as desmoglein 1-3 and desmocollins. Desmosomal cadherins showed differentiation-specific expression in the human epidermis, although the functional significance of this differential expression is not fully understood. Desmocollin-1 can be found in the upper layers. The expression of desmocollin-2 varies in the basal and suprabasal layers. And desmocollin-3 is expressed more evenly throughout the suprabasal layers.

Réactivité croisée (Details): Human. Mouse. Rat.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogène: Recombinant full-length human DSC2 protein

Clone: RDSC2-3437

Isotype: IgG1 kappa

Information d'application

Indications d'application:

Known_Application: ELISA (For coating, order Ab without BSA), Optimal dilution for a specific application should be determined.

Positive_Control: HeLa cells. Skin tissue.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Date de péremption: 24 months

Détails sur Desmocollin 2

Antigène: Desmocollin 2 (DSC2)

Autre désignation: DSC2 (DSC2 Produits)

Synonymes: anticorps ARVD11, anticorps CDHF2, anticorps DG2, anticorps DGII/III, anticorps DSC3, anticorps AW228162, anticorps Dsc2a, anticorps Dsc2b, anticorps DSC2, anticorps desmocollin 2, anticorps DSC2, anticorps Dsc2

Sujet: ARVD11, Cadherin family member 2, CDHF2, Desmocollin-2, Desmocollin-3, Desmosomal glycoprotein II and III, Desmosomal glycoprotein II, Desmosomal glycoprotein III, DG2, DGII/III, DSC2, DSC3,Desmocollin-2/3
Cellular localisation: Cell surface

Poids moléculaire: 110kDa (DSC2), 100kDa (DSC3)

ID gène: 1824, 95612

UniProt: Q02487