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IGHG4 anticorps

IGHG4 Reactivité: Humain ISt, IHC (f) Hôte: Souris Monoclonal IGHG4-1345 unconjugated
N° du produit ABIN6937504
  • Antigène Tous les produits IGHG4
    IGHG4 (Immunoglobulin Heavy Constant gamma 4 (G4m Marker) (IGHG4))
    Reactivité
    • 15
    • 1
    • 1
    Humain
    Hôte
    • 11
    • 4
    Souris
    Clonalité
    • 10
    • 5
    Monoclonal
    Conjugué
    • 10
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp IGHG4 est non-conjugé
    Application
    • 10
    • 7
    • 5
    • 4
    • 3
    • 2
    • 1
    Immunostaining (ISt), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
    Specificité
    The regions of relatively constant sequence beyond the variable regions of immunoglobulins are termed constant regions (C regions) and are present in both the heavy and light chains. With very few exceptions, the sites of attachment for carbohydrates on immunoglobulins are located in these C regions. These regions also function to hold the variable regions together by using the disulfide bond between them. The C regions facilitate interaction with the antigen by increasing the maximum rotation of the immunoglobulin arms. Reportedly, a large population of patients with recurrent respiratory tract infection has low IgG4 concentrations. IgG4-related sclerosing disease has been recognized as a systemic disease entity characterized by an elevated serum IgG4 level, sclerosing fibrosis, and diffuse lymphoplasmacytic infiltration with the presence of many IgG4-positive plasma cells.IgG4 is overexpressed in inflammatory pseudotumor (IPT) and under expressed in inflammatory myofibroblastic tumor (IMT). In pulmonary nodular lymphoid hyperplasia (PNLH), there are an increased number of IgG4+ plasma cells.
    Réactivité croisée (Details)
    Human.
    Purification
    1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
    Immunogène
    Recombinant human IGHG4 fragment
    Clone
    IGHG4-1345
    Isotype
    IgG1 kappa
  • Indications d'application

    Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues is enhanced by heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0 for 45 min at 95°C followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

    Positive_Control: Tonsil.

    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    Prepared in 10 mM PBS, WITHOUT BSA and Azide.
    Agent conservateur
    Azide free
    Stock
    -20 °C,-80 °C
    Stockage commentaire
    Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
    Date de péremption
    24 months
  • Antigène
    IGHG4 (Immunoglobulin Heavy Constant gamma 4 (G4m Marker) (IGHG4))
    Autre désignation
    IGHG4 (IGHG4 Produits)
    Synonymes
    anticorps immunoglobulin heavy constant gamma 4 (G4m marker), anticorps IGHG4
    Sujet
    Ig gamma 4 chain C region, IGHG4, Immunoglobulin heavy constant gamma 4 (G4m marker),IgG4 (Ig Heavy Constant Gamma 4) (G4m Marker)
    Cellular localisation: Cytoplasmic
    Poids moléculaire
    150kDa
    ID gène
    3503, 510635
    UniProt
    P01861
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