MBD1 anticorps
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- Antigène Voir toutes MBD1 Anticorps
- MBD1 (Methyl-CpG Binding Domain Protein 1 (MBD1))
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp MBD1 est non-conjugé
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Application
- Immunohistochemistry (IHC), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
- Specificité
- DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. MBD1 has also been predicted to be involved in the development and progression of tumors, and it has been shown that MBD1 is significantly upregulated in pancreatic cancer tissues when compared with surrounding normal tissues. Furthermore, MBD1 may serve as a potential therapeutic target for pancreatic cancer.
- Réactivité croisée (Details)
- Human.
- Purification
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- Immunogène
- Recombinant human MBD1 protein
- Clone
- CPTC-MBD1-1
- Isotype
- IgG1 kappa
- Top Product
- Discover our top product MBD1 Anticorps primaire
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- Indications d'application
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Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 min at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.
Positive_Control: Human tonsil or colon (IHC).
- Restrictions
- For Research Use only
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- Concentration
- 1.0 mg/mL
- Buffer
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- Agent conservateur
- Azide free
- Stock
- -20 °C,-80 °C
- Stockage commentaire
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- Date de péremption
- 24 months
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- Antigène
- MBD1 (Methyl-CpG Binding Domain Protein 1 (MBD1))
- Autre désignation
- MBD1 (MBD1 Produits)
- Synonymes
- anticorps CXXC3, anticorps PCM1, anticorps RFT, anticorps Cxxc3, anticorps CCDC11, anticorps methyl-CpG binding domain protein 1, anticorps MBD1, anticorps Mbd1
- Sujet
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CXXC-type zinc finger protein 3, CXXC3, MBD1, MECP1 COMPLEX, Methyl-CpG-binding domain protein 1 (MBD1), Protein containing methyl-CpG-binding domain 1 (PCM1), Regulator of fibroblast growth factor 2 (FGF 2) transcription (RFT),MBD1 (Methyl-CpG Binding Domain Protein 1)
Cellular localisation: Nuclear speckles. Chromosome. - Poids moléculaire
- 80kDa
- ID gène
- 4152, 405610
- UniProt
- Q9UIS9
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