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MUC4 anticorps (AA 1730-1864)

MUC4 Reactivité: Humain IHC (f) Hôte: Souris Monoclonal MUC4-3084 unconjugated
N° du produit ABIN6937954
  • Antigène Voir toutes MUC4 Anticorps
    MUC4 (Mucin 4, Cell Surface Associated (MUC4))
    Épitope
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 1730-1864
    Reactivité
    • 37
    • 13
    • 3
    Humain
    Hôte
    • 30
    • 8
    Souris
    Clonalité
    • 22
    • 16
    Monoclonal
    Conjugué
    • 22
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp MUC4 est non-conjugé
    Application
    • 21
    • 8
    • 7
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
    Specificité
    The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins called mucins. These glycoproteins play important roles in the protection of the epithelial cells and have been implicated in epithelial renewal and differentiation. This gene encodes an integral membrane glycoprotein found on the cell surface, although secreted isoforms may exist. MUC-4 transcripts have been detected in normal respiratory epithelium and lung. MUC-4 is a very specific (100 % ) and sensitive (90 %) marker of lung adenocarcinomas and is negative for mesotheliomas. Reportedly, MUC-4 expression in invasive ductal carcinoma of the pancreas is an independent factor for poor prognosis.
    Réactivité croisée (Details)
    Human.
    Purification
    1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
    Immunogène
    Recombinant fragment (around aa 1730-1864) of human MUC4 protein (exact sequence is proprietary)
    Clone
    MUC4-3084
    Isotype
    IgG1 kappa
    Top Product
    Discover our top product MUC4 Anticorps primaire
  • Indications d'application

    Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.

    Positive_Control: Stomach, Colon or esophagus.

    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    Prepared in 10 mM PBS, WITHOUT BSA and Azide.
    Agent conservateur
    Azide free
    Stock
    -20 °C,-80 °C
    Stockage commentaire
    Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
    Date de péremption
    24 months
  • Antigène
    MUC4 (Mucin 4, Cell Surface Associated (MUC4))
    Autre désignation
    MUC4 (MUC4 Produits)
    Synonymes
    anticorps 4933405I11Rik, anticorps Asgp, anticorps ASGP, anticorps HSA276359, anticorps MUC-4, anticorps ASGP-1, anticorps Psmc, anticorps mucin 4, anticorps mucin 4, cell surface associated, anticorps Muc4, anticorps MUC4
    Sujet
    Ascites sialoglycoprotein 1 / 2, ASGP, ASGP-1, ASGP-2, MUC-4, MUC4, Mucin 4 cell surface associated, Mucin 4 tracheobronchial, Mucin-4 beta chain, Pancreatic adenocarcinoma mucin, Testis mucin, Tracheobronchial mucin,MUC4 (Mucin 4 / Gastric Mucin)
    Cellular localisation: Cytoplasmic
    Poids moléculaire
    235kDa
    ID gène
    4585, 369646
    UniProt
    Q99102
    Pathways
    Regulation of Leukocyte Mediated Immunity
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