SPTAN1 anticorps (AA 2351-2475)
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- Antigène Voir toutes SPTAN1 Anticorps
- SPTAN1 (Spectrin alpha Chain, Brain (SPTAN1))
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Épitope
- AA 2351-2475
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp SPTAN1 est non-conjugé
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Application
- Immunohistochemistry (IHC), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
- Specificité
- Spectrin, an actin binding protein that is a major component of the cytoskeletal superstructure of the erythrocyte plasma membrane, is essential in determining the properties of the membrane including its shape and deformability. Spectrins function as membrane organizers and stabilizers, composed of nonhomologous i± and i² chains, which aggregate side-to-side in an antiparallel fashion to form dimers, tetramers, and higher polymers. Spectrin i± I and spectrin i² I are present in erythrocytes, whereas spectrin i± II (also designated fodrin i±) and spectrin i² II (also designated fodrin i²) are present in other somatic cells. The spectrin tetramers in erythrocytes act as barriers to lateral diffusion, but spectrin dimers seem to lack this function. Activation of calpain results in the breakdown of spectrin i± II, a neuronal cytoskeleton protein.
- Réactivité croisée (Details)
- Human. Others not known.
- Purification
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- Immunogène
- Recombinant fragment of human SPTAN1 protein (around aa 2351-2475) (exact sequence is proprietary))
- Clone
- SPTAN1-3352
- Isotype
- IgG2c kappa
- Top Product
- Discover our top product SPTAN1 Anticorps primaire
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- Indications d'application
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Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.
Positive_Control: Human colon or kidney tissues (IHC).
- Restrictions
- For Research Use only
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- Concentration
- 1.0 mg/mL
- Buffer
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- Agent conservateur
- Azide free
- Stock
- -20 °C,-80 °C
- Stockage commentaire
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- Date de péremption
- 24 months
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- Antigène
- SPTAN1 (Spectrin alpha Chain, Brain (SPTAN1))
- Autre désignation
- SPTAN1 (SPTAN1 Produits)
- Synonymes
- anticorps im:7157190, anticorps wu:fa20e05, anticorps wu:fb33g08, anticorps wu:fk32a10, anticorps zgc:112229, anticorps 2610027H02Rik, anticorps Spna-2, anticorps Spna2, anticorps EIEE5, anticorps NEAS, anticorps SPTA2, anticorps A2a, anticorps IPF, anticorps SPECA, anticorps spectrin alpha, non-erythrocytic 1, anticorps spectrin, alpha, non-erythrocytic 1, anticorps SPTAN1, anticorps sptan1, anticorps Sptan1
- Sujet
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Alpha-II spectrin, brain, EIEE5, Fodrin alpha chain, NEAS, Non erythrocytic spectrin alpha, non-erythroid alpha chain, SPECA, Spectrin alpha chain brain, Spectrin, alpha, non-erythrocytic 1 (alpha-fodrin), Spna2, SPTA2,Fodrin / Alpha Spectrin II (SPTAN1) / NEAS
Cellular localisation: Cytoplasm - Poids moléculaire
- 240kDa
- ID gène
- 6709, 372331
- UniProt
- Q13813
- Pathways
- Caspase Cascade in Apoptosis, Regulation of Actin Filament Polymerization
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