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MERTK anticorps (AA 55-148)

MERTK Reactivité: Humain IHC, IHC (f) Hôte: Souris Monoclonal MERTK-3015 unconjugated
N° du produit ABIN6939061
  • Antigène Voir toutes MERTK Anticorps
    MERTK (C-Mer Proto-Oncogene Tyrosine Kinase (MERTK))
    Épitope
    • 13
    • 10
    • 8
    • 8
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 55-148
    Reactivité
    • 70
    • 36
    • 27
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 65
    • 9
    • 2
    • 1
    Souris
    Clonalité
    • 59
    • 18
    Monoclonal
    Conjugué
    • 43
    • 9
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp MERTK est non-conjugé
    Application
    • 48
    • 45
    • 32
    • 14
    • 12
    • 9
    • 8
    • 8
    • 7
    • 2
    • 1
    • 1
    • 1
    • 1
    Immunohistochemistry (IHC), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
    Specificité
    MerTK, also called c-Mer, is a member of the Mer/Axl/Tyro3 receptor kinase family. It is a 984 residue transmembrane protein made up of one tyrosine kinase domain, two Fibronectin type-III domains and two immunoglobulinlike C2-type domains. MerTK is the mammalian ortholog of the chicken retroviral oncogene product v-Eyk. This protein plays a critical role in macrophage activation, platelet aggregation, clot stability and the efficient removal of apoptotic cells. Specifically, MerTK acts as a signaling molecule, triggering outer segment ingestion in the retinal pigment epithelium (RPE) phagocytic process. Evidence suggests that MerTK signals via interaction with phosphatidylinositol-specific phospholipase C 2). When the gene encoding for MerTK is mutated, the RPE phagocytosis pathway is disrupted and autosomal recessive retinitis pigmentosa (RP) may result, leading to degeneration of retinal photoreceptor cells.
    Réactivité croisée (Details)
    Human,
    Purification
    200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G.
    Immunogène
    Recombinant human MERTK protein fragment (around aa 55-148) (exact sequence is proprietary)
    Clone
    MERTK-3015
    Isotype
    IgG2a
    Top Product
    Discover our top product MERTK Anticorps primaire
  • Indications d'application

    Positive Control: Human colon tissue (IHC).

    Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.

    Restrictions
    For Research Use only
  • Concentration
    200 μg/mL
    Buffer
    Prepared in 10 mM PBS with 0.05 % BSA and 0.05 % azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-80 °C
    Stockage commentaire
    Antibody with azide - store at 2 to 8 °C. Antibody is stable for 24 months. Non-hazardous. Also available WITHOUT BSA & azide at 1.0mg/ml.
    Date de péremption
    24 months
  • Antigène
    MERTK (C-Mer Proto-Oncogene Tyrosine Kinase (MERTK))
    Autre désignation
    MERTK (MERTK Produits)
    Synonymes
    anticorps MER, anticorps RP38, anticorps c-mer, anticorps Eyk, anticorps Mer, anticorps Nyk, anticorps nmf12, anticorps rdy, anticorps C-EYK, anticorps MERTK, anticorps DKFZp469D2215, anticorps si:ch1073-268l12.2, anticorps MER proto-oncogene, tyrosine kinase, anticorps c-mer proto-oncogene tyrosine kinase, anticorps c-mer proto-oncogene tyrosine kinase a, anticorps MERTK, anticorps Mertk, anticorps mertka
    Sujet
    CEyk, MER receptor tyrosine kinase, MERK, MERPEN, nmf12, Nyk, Proto-oncogene c-Mer, RP38, STK kinase,MerTK (Innate Immune Checkpoint)
    Cellular localisation: Cell surface.
    Poids moléculaire
    110kDa
    ID gène
    10461, 306178
    UniProt
    Q12866
    Pathways
    Signalisation RTK
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