CFTR anticorps
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- Antigène Voir toutes CFTR Anticorps
- CFTR (Cystic Fibrosis Transmembrane Conductance Regulator (ATP-Binding Cassette Sub-Family C, Member 7) (CFTR))
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp CFTR est non-conjugé
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Application
- Immunofluorescence (IF), Immunostaining (ISt), Western Blotting (WB), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
- Specificité
- Recognizes a protein of 165-170kDa, identified as cystic fibrosis transmembrane conductance regulator (CFTR). CFTR is composed of two membrane-spanning domains (MSD), two nucleotide-binding domains (NBD), and an R domain. It is structurally similar to multidrug resistance (Mdr1) protein and both are members of the superfamily of ATP-binding cassette (ABC) transporters, also known as traffic ATPases, which are implicated in the movement of various substrates. The CFTR protein is a small conductance adenosine 3',5'-cyclic monophosphate (cAMP)-activated chloride ion channel found in the apical membranes of epithelia within the pancreas, airway, intestine, bile duct, sweat gland, and male genital ducts. CFTR is a valuable marker of human pancreatic duct cell development and differentiation.
- Réactivité croisée (Details)
- Human, Mouse,
- Purification
- 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G.
- Immunogène
- Recombinant human CFTR fragment
- Clone
- SPM176
- Isotype
- IgG2a
- Top Product
- Discover our top product CFTR Anticorps primaire
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- Indications d'application
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Positive Control: MOLT-4 cells. Pancreas, Kidney or Placenta.
Known Application: Immunofluorescence (1-2 μg/mL), Western Blot (1-2 μg/mL), Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues is enhanced by heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0 for 45 min at 95°C followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.
- Restrictions
- For Research Use only
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- Concentration
- 200 μg/mL
- Buffer
- Prepared in 10 mM PBS with 0.05 % BSA and 0.05 % azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C,-80 °C
- Stockage commentaire
- Antibody with azide - store at 2 to 8 °C. Antibody is stable for 24 months. Non-hazardous. Also available WITHOUT BSA & azide at 1.0mg/ml.
- Date de péremption
- 24 months
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- Antigène
- CFTR (Cystic Fibrosis Transmembrane Conductance Regulator (ATP-Binding Cassette Sub-Family C, Member 7) (CFTR))
- Autre désignation
- CFTR (CFTR Produits)
- Synonymes
- anticorps ABC35, anticorps ABCC7, anticorps CF, anticorps CFTR/MRP, anticorps MRP7, anticorps TNR-CFTR, anticorps dJ760C5.1, anticorps CFTR, anticorps AW495489, anticorps Abcc7, anticorps RGD1561193, anticorps abc35, anticorps abcc7, anticorps cftr/mrp, anticorps mrp7, anticorps tnr-cftr, anticorps xcftr, anticorps si:dkey-270i2.2, anticorps cystic fibrosis transmembrane conductance regulator, anticorps cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7), anticorps CFTR, anticorps cftr-A, anticorps Cftr, anticorps cftr
- Sujet
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ABC35, ATP Binding Cassette Superfamily C Member 7 (ABCC7), cAMP-dependent chloride channel, CFTR, CFTR/MRP, Channel conductance-controlling ATPase, Cystic Fibrosis Transmembrane Conductance Regulator, MRP7, TNR CFTR,CFTR (Cystic Fibrosis Transmembrane Conductance Regulator)
Cellular localisation: Cell Surface and Cytoplasmic - Poids moléculaire
- 165-170kDa
- ID gène
- 1080, 489786, 621460
- UniProt
- P13569
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