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CTNND1 anticorps

CTNND1 Reactivité: Humain, Souris, Rat ELISA, IF, FACS, Coat Hôte: Souris Monoclonal 25a unconjugated
N° du produit ABIN6939213
  • Antigène Voir toutes CTNND1 Anticorps
    CTNND1 (Catenin (Cadherin-Associated Protein), delta 1 (CTNND1))
    Reactivité
    • 142
    • 125
    • 53
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 149
    • 24
    Souris
    Clonalité
    • 145
    • 28
    Monoclonal
    Conjugué
    • 65
    • 12
    • 7
    • 6
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp CTNND1 est non-conjugé
    Application
    • 113
    • 54
    • 54
    • 44
    • 34
    • 30
    • 29
    • 23
    • 14
    • 14
    • 14
    • 4
    • 4
    • 3
    • 1
    ELISA, Immunofluorescence (IF), Flow Cytometry (FACS), Coating (Coat)
    Purification
    Purified by Protein A/G
    Immunogène
    Mouse p120 Catenin (pY96)
    Clone
    25a
    Isotype
    IgG1 kappa
    Top Product
    Discover our top product CTNND1 Anticorps primaire
  • Indications d'application

    Positive Control: HeLa cells. HeLa whole cell lysate.

    Known Application: ELISA (For coating, order antibody without BSA), Flow Cytometry (0.5-1 μg/million cells), Immunofluorescence (1-2 μg/mL), Optimal dilution for a specific application should be determined.

    Restrictions
    For Research Use only
  • Concentration
    200 μg/mL
    Buffer
    10 mM PBS with 0.05 % BSA & 0.05 % azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-80 °C
    Stockage commentaire
    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
    Date de péremption
    24 months
  • Antigène
    CTNND1 (Catenin (Cadherin-Associated Protein), delta 1 (CTNND1))
    Autre désignation
    CTNND1 (CTNND1 Produits)
    Synonymes
    anticorps CAS, anticorps CTNND, anticorps P120CAS, anticorps P120CTN, anticorps p120, anticorps p120(CAS), anticorps p120(CTN), anticorps Catns, anticorps cas, anticorps Xp120, anticorps ctnnd, anticorps p120cas, anticorps p120ctn, anticorps p120(ctn), anticorps Xp120(ctn), anticorps p120-catenin, anticorps CTNND1, anticorps AA409437, anticorps AU019353, anticorps Ctnnd, anticorps P120, anticorps mKIAA0384, anticorps catenin delta 1, anticorps catenin (cadherin-associated protein), delta 1, anticorps catenin (cadherin associated protein), delta 1, anticorps catenin delta 1 L homeolog, anticorps CTNND1, anticorps Ctnnd1, anticorps ctnnd1, anticorps ctnnd1.L
    Sujet
    The membrane associated protein pp120 Src substrate (p120 Catenin, p120cas) was identified as a tyrosine kinase substrate that is phosphorylated in Src transformed cells or in response to growth factor stimulation. It shares structural similarity with the Drosophila Armadillo protein and the vertebrate beta-catenin and gamma-catenin proteins. Its characteristic Arm domain that is composed of 42-amino acid motif repeats evidences this similarity. In the cell, p120 Catenin is localized to the E-Cadherin/catenins cell adhesion complex. Like beta- and gamma-catenin, p120 Catenin directly associates with the cytoplasmic C-terminus of E-Cadherin via its Arm domain and may similarly interact with other Cadherins. It exists as four isoforms that range in size from 90-115 kDa. Expression of these isoforms is heterogeneous in human carcinomas, suggesting that altered pp120 expression contributes to malignancy due to loss of functional cell adhesions. Multiple tyrosine residues (Y96, Y112, Y228, Y280, Y257, Y291, Y296, and Y302) in p120 Catenin are phosphorylated by Src and these phosphorylations may facilitate interaction with PTP1C/SHP-1 in response to EGF stimulation. Thus, p120 Catenin is an Arm domain protein that interacts with both cell adhesion molecules, such as cadherins and cell signaling molecules, such as PTP1C.
    Poids moléculaire
    120kDa
    ID gène
    1500
    UniProt
    O60716
    Pathways
    EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Cell-Cell Junction Organization, CXCR4-mediated Signaling Events, Platelet-derived growth Factor Receptor Signaling
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