Decorin anticorps (AA 212-336)

N° du produit ABIN6939230

Détail du produit anti-Decorin anticorps

Antigène: Decorin (DCN)

Épitope: AA 212-336

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Decorin est non-conjugé

Application: Immunohistochemistry (IHC), Staining Methods (StM)

Purification: Purified by Protein A/G

Immunogène: Recombinant human Decorin protein fragment (aa212-336) (exact sequence is proprietary)

Clone: DCN-3523

Isotype: IgG2b kappa

Information d'application

Indications d'application:

Positive Control: Human prostate or skin tissue (IHC).

Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur Decorin

Antigène: Decorin (DCN)

Autre désignation: DCN (DCN Produits)

Synonymes: anticorps CSCD, anticorps DSPG2, anticorps PG40, anticorps PGII, anticorps PGS2, anticorps SLRR1B, anticorps DC, anticorps mDcn, anticorps cscd, anticorps dspg2, anticorps pg40, anticorps pgii, anticorps pgs2, anticorps slrr1b, anticorps decorin, anticorps decorin L homeolog, anticorps DCN, anticorps Dcn, anticorps dcn.L, anticorps dcn

Sujet: Decorin is a small leucine-rich proteoglycan (SLRP) family member that consists of a glycosaminoglycan chain-containing core protein. The core protein contains ten leucine rich repeats that contain sites for glycosylation, flanked by disulfide bond stabilizing loops. Decorin binds to Collagen Type I, II and IV in vivo and promotes the formation of fibers with variations in stability and solubility. The Decorin core protein binds to growth factors, intercellular matrix molecules, such as Fibronectin and Thrombospondin, and to the Decorin endocytosis receptor. Decorin binds to and inhibits TGF and is a direct or indirect negative modulator of TGF synthesis. Inhibition of Decorin core protein gene expression by the combination of IFN- and TNF may contribute to cartilage destruction that is characteristic of inflammatory joint diseases. The human Decorin gene maps to chromosome 12q21.33 and encodes a 359 amino acid protein.

Poids moléculaire: 43kDa

ID gène: 1634

UniProt: P07585

Pathways: Glycosaminoglycan Metabolic Process