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Desmocollin 2 anticorps (Extracellular Domain)

DSC2 Reactivité: Humain, Souris, Rat WB, IHC, IF, FACS, StM Hôte: Souris Monoclonal 7G6 unconjugated
N° du produit ABIN6939250
  • Antigène Voir toutes Desmocollin 2 (DSC2) Anticorps
    Desmocollin 2 (DSC2)
    Épitope
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Extracellular Domain
    Reactivité
    Humain, Souris, Rat
    Hôte
    • 18
    • 10
    • 2
    Souris
    Clonalité
    • 22
    • 8
    Monoclonal
    Conjugué
    • 23
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp Desmocollin 2 est non-conjugé
    Application
    • 17
    • 11
    • 8
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS), Staining Methods (StM)
    Purification
    Purified by Protein A/G
    Immunogène
    Human desmocollin-2 extracellular domain
    Clone
    7G6
    Isotype
    IgG1 kappa
    Top Product
    Discover our top product DSC2 Anticorps primaire
  • Indications d'application

    Positive Control: HeLa cells. Skin tissue.

    Known Application: Flow Cytometry (0.5-1 μg/million cells), Immunofluorescence (1-2 μg/mL), Western Blot (0.5-1.0 μg/mL), Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

    Restrictions
    For Research Use only
  • Concentration
    200 μg/mL
    Buffer
    10 mM PBS with 0.05 % BSA & 0.05 % azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-80 °C
    Stockage commentaire
    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
    Date de péremption
    24 months
  • Antigène
    Desmocollin 2 (DSC2)
    Autre désignation
    DSC2 (DSC2 Produits)
    Synonymes
    anticorps ARVD11, anticorps CDHF2, anticorps DG2, anticorps DGII/III, anticorps DSC3, anticorps AW228162, anticorps Dsc2a, anticorps Dsc2b, anticorps DSC2, anticorps desmocollin 2, anticorps DSC2, anticorps Dsc2
    Sujet
    Desmosomes are intercellular adhering junctions that represent cell surface attachment sites for intermediate filament. The desmosome is subdivided into two regions. The plaque region lies adjacent to the plasma, and is believed to contain molecules that attach the intermediate filament cytoskeleton to the desmosome. The core region is composed of transmembrane glycoproteins that are thought to mediate cell-cell adhesion. Desmogleins and desmocollins are the main desmosomal transmembrane proteins. These desmosomal glycoproteins belong to the members of the cadherin family of adhesion molecules. Three different isoforms of both desmogleins and desmocollins have been identified, named as desmoglein 1-3 and desmocollins. Desmosomal cadherins showed differentiation-specific expression in the human epidermis, although the functional significance of this differential expression is not fully understood. Desmocollin-1 can be found in the upper layers. The expression of desmocollin-2 varies in the basal and suprabasal layers. And desmocollin-3 is expressed more evenly throughout the suprabasal layers.
    Poids moléculaire
    110kDa (DSC2), 100kDa (DSC3)
    ID gène
    1824
    UniProt
    Q02487
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