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Thymidine Phosphorylase anticorps

TYMP Reactivité: Humain, Rat, Souris WB, IHC, IP, StM Hôte: Souris Monoclonal P-GF-44C unconjugated
N° du produit ABIN6939276
  • Antigène Voir toutes Thymidine Phosphorylase (TYMP) Anticorps
    Thymidine Phosphorylase (TYMP)
    Reactivité
    • 68
    • 28
    • 24
    • 1
    • 1
    • 1
    Humain, Rat, Souris
    Hôte
    • 60
    • 15
    • 1
    Souris
    Clonalité
    • 59
    • 17
    Monoclonal
    Conjugué
    • 34
    • 8
    • 6
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    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
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    • 1
    Cet anticorp Thymidine Phosphorylase est non-conjugé
    Application
    • 62
    • 29
    • 20
    • 14
    • 13
    • 13
    • 9
    • 5
    • 5
    • 3
    • 3
    • 2
    • 2
    • 1
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    Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Staining Methods (StM)
    Specificité
    Recognizes a protein (amino acid 482) of 55 kDa (in vivo 110 kDa homodimer), identified as platelet-derived endothelial growth factor (PD-ECGF), same as thymidine phosphorylase (TP) or gliostatin. In the presence of inorganic orthophosphate, it catalyzes the reversible phospholytic cleavage of thymidine and deoxyuridine to their corresponding bases and 2-deoxyribose-1-phosphate. It is both chemotactic and mitogenic for endothelial cells and a non-heparin binding angiogenic factor present in platelets. Its enzymatic activity is crucial for angiogenic activity (metabolite is angiogenic). Higher levels of serum TP/PD-ECGF are observed in cancer patients. It is also involved in transformation of fluoropyrimidines, cytotoxic agents used in the treatment of a variety of malignancies, into active cytotoxic metabolites (e.g. 5'-deoxy-5-fluorouridine to 5-FU). High intra-cellular levels of TP/PD-ECGF are associated with increased chemosensitivity to such antimetabolites.
    Purification
    Purified by Protein A/G
    Immunogène
    Recombinant full-length human Thymidine Phosphorylase (TP / PD-ECGF) protein
    Clone
    P-GF-44C
    Isotype
    IgG1 kappa
    Top Product
    Discover our top product TYMP Anticorps primaire
  • Indications d'application

    Positive Control: HUVEC cells. Breast, Bladder, Lung or Kaposi tumors.

    Known Application: Western Blot (0.5-1 μg/mL), Immunoprecipitation (0.5-1 μg/500 μg protein lysate), Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

    Restrictions
    For Research Use only
  • Concentration
    200 μg/mL
    Buffer
    10 mM PBS with 0.05 % BSA & 0.05 % azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-80 °C
    Stockage commentaire
    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
    Date de péremption
    24 months
  • Antigène
    Thymidine Phosphorylase (TYMP)
    Autre désignation
    TYMP (TYMP Produits)
    Synonymes
    anticorps ECGF, anticorps ECGF1, anticorps MEDPS1, anticorps MNGIE, anticorps MTDPS1, anticorps PDECGF, anticorps TP, anticorps hPD-ECGF, anticorps 2900072D10Rik, anticorps Ecgf1, anticorps PD-ECGF, anticorps Pdgfec, anticorps typh, anticorps thymidine phosphorylase, anticorps thymidine phosphorylase DeoA, anticorps AMP phosphorylase, anticorps Thymidine phosphorylase, anticorps TYMP, anticorps Tymp, anticorps deoA, anticorps Dd586_0614, anticorps Kvar_4413, anticorps NMAG_RS19330, anticorps Snov_1187, anticorps Fbal_2856, anticorps Ftrac_2071, anticorps Intca_1216, anticorps ARCVE_RS10415, anticorps Sphch_4174, anticorps Sinme_3461, anticorps METOK_RS06355, anticorps Mesop_1831, anticorps typh
    Poids moléculaire
    55kDa
    ID gène
    1890
    UniProt
    P19971
    Pathways
    Signaling Events mediated by VEGFR1 and VEGFR2
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