Recombinant Thymidine Phosphorylase anticorps

N° du produit ABIN6939278

Détail du produit anti-Thymidine Phosphorylase anticorps

Antigène: Thymidine Phosphorylase (TYMP)

Type d'anticorp: Recombinant Antibody

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp Thymidine Phosphorylase est non-conjugé

Application: Immunohistochemistry (IHC), Staining Methods (StM)

Specificité: Recognizes a protein (amino acid 482) of 55 kDa (in vivo 110 kDa homodimer), identified as platelet-derived endothelial growth factor (PD-ECGF), same as thymidine phosphorylase (TP) or gliostatin. In the presence of inorganic orthophosphate, it catalyzes the reversible phospholytic cleavage of thymidine and deoxyuridine to their corresponding bases and 2-deoxyribose-1-phosphate. It is both chemotactic and mitogenic for endothelial cells and a non-heparin binding angiogenic factor present in platelets. Its enzymatic activity is crucial for angiogenic activity (metabolite is angiogenic). Higher levels of serum TP/PD-ECGF are observed in cancer patients. It is also involved in transformation of fluoropyrimidines, cytotoxic agents used in the treatment of a variety of malignancies, into active cytotoxic metabolites (e.g. 5'-deoxy-5-fluorouridine to 5-FU). High intra-cellular levels of TP/PD-ECGF are associated with increased chemosensitivity to such antimetabolites.

Purification: Purified by Protein A/G

Immunogène: Recombinant full-length human Thymidine Phosphorylase (TP / PD-ECGF) protein

Clone: TYMP-2890R

Isotype: IgG

Information d'application

Indications d'application:

Positive Control: HUVEC cells. Breast, Bladder, Lung or Kaposi tumors.

Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur Thymidine Phosphorylase

Antigène: Thymidine Phosphorylase (TYMP)

Autre désignation: TYMP (TYMP Produits)

Synonymes: anticorps ECGF, anticorps ECGF1, anticorps MEDPS1, anticorps MNGIE, anticorps MTDPS1, anticorps PDECGF, anticorps TP, anticorps hPD-ECGF, anticorps 2900072D10Rik, anticorps Ecgf1, anticorps PD-ECGF, anticorps Pdgfec, anticorps typh, anticorps thymidine phosphorylase, anticorps thymidine phosphorylase DeoA, anticorps AMP phosphorylase, anticorps Thymidine phosphorylase, anticorps TYMP, anticorps Tymp, anticorps deoA, anticorps Dd586_0614, anticorps Kvar_4413, anticorps NMAG_RS19330, anticorps Snov_1187, anticorps Fbal_2856, anticorps Ftrac_2071, anticorps Intca_1216, anticorps ARCVE_RS10415, anticorps Sphch_4174, anticorps Sinme_3461, anticorps METOK_RS06355, anticorps Mesop_1831, anticorps typh

Poids moléculaire: 55kDa

ID gène: 1890

UniProt: P19971

Pathways: Signaling Events mediated by VEGFR1 and VEGFR2