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Recombinant EGFR anticorps

Name: Recombinant EGFR anticorps
Brand: antibodies-online
SKU: ABIN6939297
Price: 663.89 EUR
Availability: InStock

EGFR Reactivité: Humain IHC, StM Hôte: Lapin Monoclonal GFR-2968R unconjugated Recombinant Antibody

Western Blot Analysis of A431 cell lysate using EGFR-Monospecific Recombinant Rabbit Monoclonal Antibody (GFR/2968R). (Recombinant EGFR anticorps)

Analysis of Protein Array containing more than 19,000 full-length human proteins using EGFR-Monospecific Recombinant Rabbit Monoclonal Antibody (C1A/1506R) Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (Monoclonal Antibody) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. (Recombinant EGFR anticorps)

PAr

Formalin-fixed, paraffin-embedded human Placenta stained with EGFR-Monospecific Recombinant Rabbit Monoclonal Antibody (GFR/2968R). (Recombinant EGFR anticorps)

IHC

SDS-PAGE Analysis Purified EGFR-Monospecific Recombinant Rabbit Monoclonal Antibody (GFR/2968R). (Recombinant EGFR anticorps)

SDS

4 images

N° du produit ABIN6939297

Fiche de données

Antigène Voir toutes EGFR Anticorps

EGFR (Epidermal Growth Factor Receptor (EGFR))

Type d'anticorp

Recombinant Antibody
Reactivité
755

296

286

26

26

24

20

14

8

3

2

2

1

1

1

1

1

1
Humain
Hôte
579

177

14

13

5

1

1
Lapin
Anticorps secondaires appropriés
Clonalité
534

251

2
Monoclonal
Conjugué
415

58

29

22

20

17

17

16

15

15

15

12

10

10

10

10

10

10

10

10

10

8

8

5

4

4

4

4

4

2

1

1

1

1

1

1
Cet anticorp EGFR est non-conjugé
Application
539

248

152

150

131

102

102

94

82

49

37

35

34

19

11

7

5

4

4

3

3

3

3

3

3

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1
Immunohistochemistry (IHC), Staining Methods (StM)

Specificité

This MAb recognizes a protein of 170 kDa, identified as EGFR. EGFR is type I receptor tyrosine kinase with sequence homology to erbB-1, -2, -3 -4 or HER-1, -2, -3 -4. It binds to Epidermal Growth Factor (EGF), Transforming Growth Factor-a (TGF-a), Heparin-binding EGF (HB-EGF), amphiregulin, betacellulin and epiregulin. EGFR is overexpressed in tumors of breast, brain, bladder, lung, gastric, head neck, esophagus, cervix, vulva, ovary, and endometrium. It is predominantly present in squamous cell carcinomas.

Purification

Purified by Protein A/G

Immunogène

Recombinant full-length human EGFR protein

Clone

GFR-2968R

Isotype

IgG

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Indications d'application

Positive Control: A431 cells. Placenta, Breast, Colon or Bladder cancer.
Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Restrictions

For Research Use only
Concentration

200 μg/mL

Buffer

10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur

Sodium azide

Précaution d'utilisation

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock

4 °C,-80 °C

Stockage commentaire

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption

24 months
Antigène

EGFR (Epidermal Growth Factor Receptor (EGFR))

Autre désignation

EGFR (EGFR Produits)

Poids moléculaire

~170kDa (wild type) and ~145kDa (vIII variant)

ID gène

1956

UniProt

P00533

Pathways

Signalisation NF-kappaB, Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Stem Cell Maintenance, Hepatitis C, Positive Regulation of Response to DNA Damage Stimulus, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling, EGFR Downregulation, S100 Proteins