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FAT1 anticorps (Cytoplasmic Domain)

FAT1 Reactivité: Drosophila melanogaster ELISA, WB, Coat, IF Hôte: Souris Monoclonal FAT1-3D7-1 unconjugated
N° du produit ABIN6939370
  • Antigène Voir toutes FAT1 Anticorps
    FAT1 (FAT Tumor Suppressor Homolog 1 (FAT1))
    Épitope
    • 1
    • 1
    • 1
    • 1
    Cytoplasmic Domain
    Reactivité
    • 17
    • 1
    • 1
    Drosophila melanogaster
    Hôte
    • 15
    • 2
    Souris
    Clonalité
    • 15
    • 2
    Monoclonal
    Conjugué
    • 10
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp FAT1 est non-conjugé
    Application
    • 8
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    ELISA, Western Blotting (WB), Coating (Coat), Immunofluorescence (IF)
    Réactivité croisée (Details)
    Expected to cross-react with Chimpanzee. Rat (92 % . 85 % identity with immunogen. respectively) due to sequence homology.
    Purification
    Purified by Protein A/G
    Immunogène
    Cytoplasmic domain of Drosophila Fat protein.
    Clone
    FAT1-3D7-1
    Isotype
    IgM kappa
    Top Product
    Discover our top product FAT1 Anticorps primaire
  • Indications d'application

    Positive Control: Wild type imaginal discs from third instar Drosophila larvae.

    Known Application: ELISA (For coating, order antibody without BSA), Western Blot (0.5-1.0 μg/mL), Immunofluorescence (0.5-1 μg/mL), Optimal dilution for a specific application should be determined.

    Restrictions
    For Research Use only
  • Concentration
    200 μg/mL
    Buffer
    10 mM PBS with 0.05 % BSA & 0.05 % azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-80 °C
    Stockage commentaire
    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
    Date de péremption
    24 months
  • Antigène
    FAT1 (FAT Tumor Suppressor Homolog 1 (FAT1))
    Autre désignation
    FAT1 (FAT1 Produits)
    Synonymes
    anticorps CDHF7, anticorps CDHR8, anticorps FAT, anticorps ME5, anticorps hFat1, anticorps Fath, anticorps mFat1, anticorps AU023433, anticorps 2310038E12Rik, anticorps FAT1, anticorps FAT atypical cadherin 1, anticorps FAT tumor suppressor homolog 1 (Drosophila), anticorps protocadherin Fat 1, anticorps FAT1, anticorps Fat1, anticorps LOC100175143, anticorps fat1
    Sujet
    The FAT proteins are members of the Cadherin superfamily homologous to the Drosophila Fat protein that functions as a positive regulator of planar cell polarity in the Drosophila wing. FAT1 is an unusual cadherin that controls cell growth and planar polarity while acting as a tumor suppressor. FAT1 is a proximal element of a signaling pathway that determines both cellular polarity in the plane of the monolayer and directed actin-dependent cell motility. FAT1 is localized at the leading edge of lamellipodia, filopodia and microspike tips where it directly interacts with Ena/VASP proteins to regulate the actin polymerization complex. When targeted to mitochondrial outer leaflets, the cytoplasmic domain of FAT1 recruits components of the actin polymerization machinery sufficient to induce ectopic actin polymerization. FAT1 expression in vascular smooth muscle cells (VSMCs) increases significantly after arterial injury or growth factor stimulation, implicating FAT1 in the control of VSMC functions central to vascular remodeling by facilitating migration and limiting proliferation. FAT1 is also involved in psychic disorders, and its action may be of patho-physiological importance.
    Poids moléculaire
    500kDa
    ID gène
    2195
    UniProt
    Q14517
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