FCGR3A anticorps
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- Antigène Voir toutes FCGR3A Anticorps
- FCGR3A (Fc Fragment of IgG, Low Affinity IIIa, Receptor (CD16a) (FCGR3A))
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp FCGR3A est non-conjugé
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Application
- Flow Cytometry (FACS), Immunofluorescence (IF), Functional Studies (Func)
- Specificité
- It recognizes CD16 (FcgammaRIII), the low-affinity receptor for IgG with an apparent molecular weight of 50-80 kDa. Two similar genes represent CD16, CD16A (FcgammaRIIIA), which exists as a hetero-oligomeric polypeptide-anchored form in macrophages and NK cells and CD16B (FcgammaRIIIB), which exist as a monomeric GPI-anchored form in neutrophils. Furthermore, there are two known polymorphisms of CD16B, NA-1 and NA-2. Individuals homozygous for NA-2 show a lower phagocytic capacity compared with NA-1. CD16 binds IgG in the form of immune complexes and shows preferential binding of IgG1 and IgG3 isotypes and minimal binding of IgG2 and IgG4. Upon IgG binding, both CD16 isoforms initiate signal transduction cascades that lead to a variety of responses including antibody-dependent cell-mediated cytotoxicity (ADCC), phagocytosis, degranulation and proliferation.
- Purification
- Purified by Protein A/G
- Immunogène
- PBL's from a NK-leukemia patient
- Clone
- HO-80
- Isotype
- IgG2a kappa
- Top Product
- Discover our top product FCGR3A Anticorps primaire
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- Indications d'application
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Positive Control: K-562 or U-937 cells. Lymph nodes and tonsils.
Known Application: Functional Studies (Order Ab without BSA & Azide), Flow Cytometry (0.5-1 μg/million cells), Immunofluorescence (0.5-1 μg/mL), Optimal dilution for a specific application should be determined.
- Restrictions
- For Research Use only
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- Concentration
- 200 μg/mL
- Buffer
- 10 mM PBS with 0.05 % BSA & 0.05 % azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C,-80 °C
- Stockage commentaire
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Date de péremption
- 24 months
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- Antigène
- FCGR3A (Fc Fragment of IgG, Low Affinity IIIa, Receptor (CD16a) (FCGR3A))
- Autre désignation
- FCGR3A (FCGR3A Produits)
- Synonymes
- anticorps CD16, anticorps CD16A, anticorps FCG3, anticorps FCGR3, anticorps FCGRIII, anticorps FCR-10, anticorps FCRIII, anticorps FCRIIIA, anticorps IGFR3, anticorps Fcgr4, anticorps Fc fragment of IgG receptor IIIa, anticorps FCGR3A, anticorps Fcgr3a
- Poids moléculaire
- 50-80kDa
- ID gène
- 2214
- UniProt
- P08637
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