Neuregulin 1 anticorps (AA 21-242)

N° du produit ABIN6939613

Détail du produit anti-Neuregulin 1 anticorps

Antigène: Neuregulin 1 (NRG1)

Épitope: AA 21-242

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Neuregulin 1 est non-conjugé

Application: Immunohistochemistry (IHC), Staining Methods (StM)

Purification: Purified by Protein A/G

Immunogène: Recombinant fragment of human Neuregulin-1 (NRG1) protein (around aa 21-242) (exact sequence is proprietary)

Clone: NRG1-2710

Isotype: IgG1 kappa

Information d'application

Indications d'application:

Positive Control: A431, MCF-7 or T47D cells. Breast, Bladder or Thyroid Carcinoma.

Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 min at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur Neuregulin 1

Antigène: Neuregulin 1 (NRG1)

Autre désignation: NRG1 (NRG1 Produits)

Synonymes: anticorps 6030402G23Rik, anticorps ARIA, anticorps D230005F13Rik, anticorps GGF, anticorps GGFII, anticorps HRG, anticorps HRGalpha, anticorps Hgl, anticorps NDF, anticorps SMDF, anticorps GGF2, anticorps HGL, anticorps HRG1, anticorps HRGA, anticorps MST131, anticorps NRG-1, anticorps heregulin, anticorps nrg1-A, anticorps pro-neuregulin-1, anticorps NRG1, anticorps wu:fm70e01, anticorps DKFZp459A1838, anticorps neuregulin 1, anticorps histidine rich glycoprotein, anticorps neuregulin 1 L homeolog, anticorps Nrg1, anticorps NRG1, anticorps HRG, anticorps nrg1.L, anticorps nrg1

Sujet: Heregulin-1 is a membrane glycoprotein that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder (BPD).

Poids moléculaire: 26-71kDa

ID gène: 3084

UniProt: Q02297

Pathways: Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Muscle Cell Differentiation