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Recombinant IGHM anticorps

IGHM Reactivité: Humain IHC, StM Hôte: Souris Monoclonal rIM373 unconjugated Recombinant Antibody
N° du produit ABIN6939721
  • Antigène Tous les produits IGHM
    IGHM (Immunoglobulin Heavy Constant mu (IGHM))
    Type d'anticorp
    Recombinant Antibody
    Reactivité
    • 25
    • 1
    • 1
    Humain
    Hôte
    • 13
    • 12
    Souris
    Clonalité
    • 16
    • 9
    Monoclonal
    Conjugué
    • 21
    • 1
    • 1
    • 1
    • 1
    Cet anticorp IGHM est non-conjugé
    Application
    • 12
    • 12
    • 11
    • 8
    • 7
    • 6
    • 6
    • 4
    • 2
    • 1
    • 1
    • 1
    Immunohistochemistry (IHC), Staining Methods (StM)
    Specificité
    Recognizes a protein of 75 kDa, identified as mu heavy chain of human immunoglobulins. It does not cross-react with alpha (IgA), gamma (IgG), epsilon (IgE), or delta (IgD), heavy chains, T-cells, monocytes, granulocytes, or erythrocytes. Monomeric IgM is expressed as a membrane bound antibody on the surface of B cells and as a pentamer when secreted by plasma cells. IgM antibody is prominent in early immune responses to most antigens. Aberrant levels are associated with immune deficiency states, hereditary deficiencies, myeloma, Waldenstrom's macroglobulinemia, chronic infection and hepatocellular disease. This MAb is useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkin's lymphomas. The most common feature of these malignancies is the restricted expression of a single heavy chain class. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is clonal and therefore malignant.
    Purification
    Purified by Protein A/G
    Immunogène
    Heavy chain of human IgM
    Clone
    RIM373
    Isotype
    IgG1 kappa
  • Indications d'application

    Positive Control: 293T, Raji or hPBL cells. Tonsil or Spleen.

    Known Application: Immunohistochemistry (Formalin-fixed) (0.5-1 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

    Restrictions
    For Research Use only
  • Concentration
    200 μg/mL
    Buffer
    10 mM PBS with 0.05 % BSA & 0.05 % azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-80 °C
    Stockage commentaire
    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
    Date de péremption
    24 months
  • Antigène
    IGHM (Immunoglobulin Heavy Constant mu (IGHM))
    Autre désignation
    IGHM (IGHM Produits)
    Synonymes
    anticorps AI326478, anticorps Igh-6, anticorps Igh-M, anticorps Igh6, anticorps Igm, anticorps muH, anticorps ighm1, anticorps wu:fj14a08, anticorps zgc:101769, anticorps AGM1, anticorps MU, anticorps VH, anticorps immunoglobulin heavy constant mu, anticorps Ighm, anticorps ighm, anticorps IGHM
    Poids moléculaire
    50-75kDa
    ID gène
    3507
    UniProt
    P01871, P20769
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