PLK1.S anticorps

N° du produit ABIN6939848

Détail du produit anti-PLK1.S anticorps

Antigène: PLK1.S (Serine/threonine-Protein Kinase PLK1 (PLK1.S))

Reactivité: Xenopus laevis

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PLK1.S est non-conjugé

Application: Coating (Coat), ELISA, Western Blotting (WB)

Aucune reactivité croisée: Humain, Souris

Purification: Purified by Protein A/G

Immunogène: Recombinant full-length PLK1 Xenopus laevis protein

Clone: AZ44

Isotype: IgG1 kappa

Information d'application

Indications d'application:

Positive Control: Mitotic CSF Xenopus egg extract.

Known Application: ELISA (For coating, order antibody without BSA), Western Blot (1-2 μg/mL)Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur PLK1.S

Antigène: PLK1.S (Serine/threonine-Protein Kinase PLK1 (PLK1.S))

Autre désignation: plk1.S (PLK1.S Produits)

Sujet: Plk (for polo-like kinase) encodes a serine/threonine kinase that is closely related to polo and CDC5, genes that are required for passage through mitosis in Drosophila and Saccharomyces, respectively. Polo and Cdc5 both code for proteins that are involved in regulating the function of the mitotic spindle. Plk protein accumulates in the cell during the S and G2 phases of the cell cycle, Plk protein content and catalytic activity peak at the onset of mitosis, followed by a rapid reduction after mitosis. Plk expression is detectable in mitotically active tissues such as colon and placenta, as well as in tumors of various origins. It has also been suggested that Plk may serve as a marker of cell proliferation. Required for recovery after DNA damage checkpoint and entry into mitosis. Required for kinetochore localization of BUB1B. Phosphorylates SGOL1. Required for spindle pole localization of isoform 3 of SGOL1 and plays a role in regulating its centriole cohesion function. Phosphorylates BORA, and thereby promotes the degradation of BORA. Contributes to the regulation of AURKA function. Regulates TP53 stability through phosphorylation of TOPORS. Useful for confirming that extracts have maintained CSF status and have not yet been activated into interphase.

Poids moléculaire: 66kDa

ID gène: 380481

UniProt: P70032