Recombinant MTAP anticorps (AA 97-196)

N° du produit ABIN6940088

Détail du produit anti-MTAP anticorps

Antigène: MTAP (Methylthioadenosine phosphorylase (MTAP))

Type d'anticorp: Recombinant Antibody

Épitope: AA 97-196

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MTAP est non-conjugé

Application: Immunohistochemistry (IHC), Staining Methods (StM), Immunostaining (ISt)

Specificité: Recognizes a protein of 31 kDa, which is identified as MTAP (5'-deoxy-5'-methylthioadenosine phosphorylase). It catalyzes the reversible phosphorolysis of methylthioadenosine, which is important in polyamine metabolism and for the salvage of adenine and methionine. The gene encoding MTAP is linked to the tumor suppressor gene, p16INK4A. Deficient levels of MTAP can occur in cancers primarily through co-deletion of the MTAP gene and the p16INK4A gene. Cells expressing MTAP and possessing adenine salvage pathway activity may be less susceptible to malignancy due to growth-inhibitory actions of agents (e.g. antifolates), whose mechanism of action, in part, involves this de novo purine pathway.

Purification: Purified by Protein A/G

Immunogène: Recombinant human MTAP protein fragment (aa97-196) (exact sequence is proprietary)

Clone: RMTAP-1813

Isotype: IgG1 kappa

Information d'application

Indications d'application:

Positive Control: HepG2, A431, HeLa or MCF-7 cells. Human kidney tissues (IHC).

Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues is enhanced by boiling tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0 for 10-20 min followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur MTAP

Antigène: MTAP (Methylthioadenosine phosphorylase (MTAP))

Autre désignation: MTAP (MTAP Produits)

Synonymes: anticorps BDMF, anticorps DMSFH, anticorps DMSMFH, anticorps LGMBF, anticorps MSAP, anticorps c86fus, anticorps Cc1-6, anticorps 1300019I21Rik, anticorps MTAPase, anticorps zgc:66012, anticorps mtap, anticorps methylthioadenosine phosphorylase, anticorps 5'-methylthioadenosine phosphorylase, anticorps 6-oxopurine nucleoside phosphorylase, anticorps methylthioadenosine phosphorylase L homeolog, anticorps MTAP, anticorps Mtap, anticorps mtaP, anticorps MMAH_RS04260, anticorps TAGG_RS05050, anticorps Toce_0364, anticorps VDIS_RS03165, anticorps MFER_RS02485, anticorps Intca_0886, anticorps DESMU_RS05370, anticorps Dester_1490, anticorps ARCVE_RS05445, anticorps Mahau_1873, anticorps MZHIL_RS01440, anticorps mtap, anticorps mtap.L

Poids moléculaire: 31kDa

ID gène: 4507

UniProt: Q13126

Pathways: Ribonucleoside Biosynthetic Process, Methionine Biosynthetic Process