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Recombinant POMC anticorps (AA 1-24)

POMC Reactivité: Humain, Souris, Rat IHC, StM Hôte: Lapin Monoclonal CLIP-2040R unconjugated Recombinant Antibody
N° du produit ABIN6940344
  • Antigène Voir toutes POMC Anticorps
    POMC (Proopiomelanocortin (POMC))
    Type d'anticorp
    Recombinant Antibody
    Épitope
    • 16
    • 9
    • 7
    • 6
    • 6
    • 5
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 1-24
    Reactivité
    • 59
    • 38
    • 36
    • 6
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 52
    • 32
    • 1
    Lapin
    Clonalité
    • 53
    • 32
    Monoclonal
    Conjugué
    • 55
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp POMC est non-conjugé
    Application
    • 32
    • 28
    • 27
    • 23
    • 17
    • 13
    • 13
    • 13
    • 9
    • 8
    • 5
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    Immunohistochemistry (IHC), Staining Methods (StM)
    Specificité
    ACTH (same as Corticotropin) is a 39 amino acid active peptide produced by the anterior pituitary. This MAb is specific to Synacthen (aa1-24 of ACTH), does not react with CLIP (aa17-39 of ACTH). POMC (pro-opiomelanocortin or corticotropin-lipotropin) is a 267 amino acid polypeptide hormone precursor that goes through extensive, tissue-specific posttranslational processing by convertases. POMC is cleaved into ten hormone chains named NPP, ACTH, alpha-MSH (Melanocyte Stimulating Hormone), beta-MSH, gamma-MSH, CLIP (corticotropin-like intermediary peptide), Lipotropin-beta, Lipotropin-gamma, beta-endorphin and Met-enkephalin. ACTH is also produced by cells of immune system (T-cells, B-cells, and macrophages) in response to stimuli associated with stress. Anti-ACTH is a useful marker in classification of pituitary tumors and the study of pituitary disease. It reacts with ACTH-producing cells (corticotrophs).It also may react with other tumors (e.g. some small cell carcinomas of the lung) causing paraneoplastic syndromes by secreting ACTH. '
    Réactivité croisée (Details)
    Expected to show a broad species reactivity.
    Purification
    Purified by Protein A/G
    Immunogène
    Synthetic peptide corresponding to aa1-24 of human ACTH
    Clone
    CLIP-2040R
    Isotype
    IgG
    Top Product
    Discover our top product POMC Anticorps primaire
  • Indications d'application

    Positive Control: Normal pituitary gland or pituitary tumor.

    Known Application: Immunohistochemistry (Formalin-fixed) (0.5-1 μg/mL for 30 minutes at RT) (Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

    Restrictions
    For Research Use only
  • Concentration
    200 μg/mL
    Buffer
    10 mM PBS with 0.05 % BSA & 0.05 % azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-80 °C
    Stockage commentaire
    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
    Date de péremption
    24 months
  • Antigène
    POMC (Proopiomelanocortin (POMC))
    Autre désignation
    POMC (POMC Produits)
    Synonymes
    anticorps MSH, anticorps ACTH, anticorps pomc, anticorps SI:bZ36D5.1, anticorps SI:bZ36D5.4, anticorps si:bz36d5.2, anticorps BE, anticorps Beta-LPH, anticorps Clip, anticorps Gamma-LPH, anticorps Npp, anticorps Pomc-1, anticorps Pomc1, anticorps alpha-MSH, anticorps alphaMSH, anticorps beta-MSH, anticorps gamma-MSH, anticorps CLIP, anticorps LPH, anticorps NPP, anticorps POC, anticorps Pomc2, anticorps proopiomelanocortin a, anticorps pro-opiomelanocortin-alpha, anticorps proopiomelanocortin, anticorps pomca, anticorps Pomc, anticorps POMC
    Poids moléculaire
    ACTH is ~5kDa, and the POMC precursor is ~30kDa. The molecular weight of POMC depends upon isoform variation and post-translational modifications.
    ID gène
    5443
    UniProt
    P01189
    Pathways
    Metabolism of Steroid Hormones and Vitamin D, Peptide Hormone Metabolism, Hormone Activity, Feeding Behaviour
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