PPP3R1 anticorps

N° du produit ABIN6940384

Détail du produit anti-PPP3R1 anticorps

Antigène: PPP3R1 (Protein Phosphatase 3, Regulatory Subunit B, alpha (PPP3R1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PPP3R1 est non-conjugé

Application: Immunohistochemistry (IHC), Staining Methods (StM)

Purification: Purified by Protein A/G

Immunogène: Recombinant full-length Calcineurin B protein

Clone: CALNB-2342

Isotype: IgG1 kappa

Information d'application

Indications d'application:

Positive Control: HeLa, MCF-7 or A431 cells. Prostate, Thyroid or Pancreas.

Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 min at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur PPP3R1

Antigène: PPP3R1 (Protein Phosphatase 3, Regulatory Subunit B, alpha (PPP3R1))

Autre désignation: PPP3R1 (PPP3R1 Produits)

Synonymes: anticorps si:ch211-274c22.8, anticorps canb, anticorps CALNB1, anticorps CNB, anticorps CNB1, anticorps CaNB1, anticorps Cnb1, anticorps MCIP1, anticorps protein phosphatase 3, regulatory subunit B, alpha a, anticorps protein phosphatase 3 regulatory subunit B, alpha S homeolog, anticorps protein phosphatase 3 regulatory subunit B, alpha, anticorps protein phosphatase 3, regulatory subunit B, alpha, anticorps protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I), anticorps ppp3r1a, anticorps ppp3r1.S, anticorps PPP3R1, anticorps Ppp3r1

Sujet: Calcineurin is an enzyme that dephosphorylates serine and threonine residues in proteins. It is a heterodimer of a 59 kDa catalytic A subunit and a 19 kDa regulatory B subunit that is activated by the binding of calcium ions and calmodulin. Calcineurin is expressed in many tissues, but its levels are highest in the brain, where it may play a role in learning and memory. It has many substrates, including NFAT, a transcription factor that is activated by dephosphorylation. Complexes of the immuno-suppressants cyclosporine and FK506 with immunophilin proteins such as cyclophilin and FKBP12 are potent and specific inhibitors of Calcineurin activity. Alterations in Calcineurin activity are suspected to play a role in cardiac hypertrophy and graft versus host disease in organ transplantation.

Poids moléculaire: 19kDa

ID gène: 5534

UniProt: P63098

Pathways: Signalisation RTK, Signalisation WNT, Fc-epsilon Receptor Signaling Pathway, Protein targeting to Nucleus, VEGF Signaling, BCR Signaling