RAD51 anticorps (AA 1-134)

N° du produit ABIN6940477

Détail du produit anti-RAD51 anticorps

Antigène: RAD51 (DNA Repair Protein Homolog 1 (RAD51))

Épitope: AA 1-134

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp RAD51 est non-conjugé

Application: Western Blotting (WB), ELISA, Coating (Coat)

Purification: Purified by Protein A/G

Immunogène: Recombinant fragment of human RAD51 protein (around aa 1-134) (exact sequence is proprietary)

Clone: RAD51-2753

Isotype: IgG

Information d'application

Indications d'application:

Positive Control: HeLa or MCF-7 cells. Colon or breast Carcinoma.

Known Application: ELISA (For coating, order Ab without BSA),Western Blot (1-2 μg/mL)Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur RAD51

Antigène: RAD51 (DNA Repair Protein Homolog 1 (RAD51))

Autre désignation: RAD51 (RAD51 Produits)

Sujet: RAD51 is one of the key factors of DNA repair by homologous recombination and has been shown to have anti-apoptotic activity in tumor cells. RAD51 protein interacts with a variety of tumor suppressor proteins including p53, BRCA1 and BRCA2. Elevated expression of RAD51 enhances radio-resistance of human tumor cells. Overexpression of RAD51 protein in tumor cells renders them resistant against cytotoxic drugs like Cisplatin. RAD51 interacts with BRCA1 and BRCA2 to influence subcellular localization and cellular response to DNA damage. BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis from deregulation of RAD51. High-level expression of RAD51 has been observed in a variety of human malignancies.RAD51 overexpression correlates with histological grading of the tumor in invasive ductal mammary carcinoma.

Poids moléculaire: 37kDa

ID gène: 5888

UniProt: Q06609

Pathways: Réparation de l'ADN